Thursday, April 12, 2012

What Is Human Hepatitis B Immunoglobulin?

Human Hepatitis B ImmunoglobulinThe Hepatitis B Immunoglobulin is extracted and isolated through cold ethanol fractionation and virus inactivation from the highly efficient plasma of healthy persons immunized with hepatitis B virus vaccine. The liquid agent of Hepatitis B immunogobulin apparent with slight opalescence is almost colorless or pale yellow. More than 90% protein contained is immunoglobulin. The apparent efficacy of antibody of hepatitis B virus is not less than 100IU/ml. The preparation is indicated for the treatment of shock causes by bleeding, wound of bum, cerebral edema; Intracranial hypertension caused by brain trauma; Byplalbuminemia and edema or ascites caused by cirrhosis or rendl diseases.
Hepatitis B immunoglobulin can only be obtained with a doctor's prescription. Therefore, please discuss with your doctor why it has been prescribed for you and the benefits and risks of this medicine.
Hepatitis B Immune Globulin (Human), Nabi-HB, is a sterile solution of immunoglobulin (5 ± 1%protein) containing antibodies to hepatitis B surface antigen (anti-HBs).  It is prepared from plasma donated by individuals with high titers of anti-HBs.  The plasma is processed using a modified Cohn 6 / Oncley 9 cold-alcohol fractionation process1,2 with two added viral reduction steps described below. Nabi-HB is formulated in 0.042-0.108 M sodium chloride, 0.10-0.20 M glycine, and 0.005-0.050% polysorbate 80, at pH 5.8-6.5.

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