β2-microglobulin (BMG) with the molecular weight of 11,800 present in the surface of all nucleated cells, especially lymphocytes and tumor cells and released into the blood circulation. It is the cell surface of human lymphocyte antigen (HLA) beta chain (light chain) part (for a single-chain polypeptide) molecules containing a disulfide bond, no sugar. The half-life of about 107 minutes, through glomerular urine is only 1% of the filtration, almost entirely by the renal tubular recovery.
β2-microglobulin in renal failure, inflammation and tumor, plasma concentrations may be elevated. The main clinical application is the monitoring of renal tubular function. Particularly for renal transplantation if rejection reactions affecting tubular function may occur in BMG excretion in urine increased. In acute leukemia and lymphoma infiltration of the nervous system, the BMG can be increased in cerebrospinal fluid. The content of micro-, commonly used radioimmunoassay method for determination of normal plasma BMG reference value of 1.0-2.6μg / L, urine 0.03-0.37mg / d.
No comments:
Post a Comment