A Basic Statement of Methyl 5,5,5-Trifluoro-2-oxo-4-(Trifluoromethyl)Pent-3-Enoate

Product name:Methyl 5,5,5-trifluoro-2-oxo-4-(trifluoromethyl)pent-3-enoate

Molecular Formula: C7H4F6O3

Molecular Weight: 250.1g/mol
Trifluoromethyl is a functional group in organofluorines that has the formula -CF3. The naming of is group is derived from the methyl group (which has the formula -CH3), by replacing each hydrogen atom by a fluorine atom. The trifluomethyl group has a significant electronegativity that is often described as being intermediate between the electronegativities of fluorine and chlorine. For this reason, trifluoromethyl-substituted compounds are often strong acids, such as trifluoromethanesulfonic acid and trifluoroacetic acid. In other cases, the trifluoromethyl group is employed to lower the basicity of organic compounds or to confer distinctive solvation properties (e.g. trifluoroethanol).
The synthesis of pyrazole derivatives has been well explored using the so-called [3+2] atom fragments, where β-diketones or α,β-unsaturated ketones are used as the 3-atom building block and hydrazines as the 2-atom fragment. In the last decade, our research group has reported the general synthesis of 1,1,1-trihalo-4-alkoxy-3-alken-2-ones, 3-atom building blocks, and demonstrated their usefulness in heterocyclic preparations.

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