Description of CRF (human, rat) Acetate

Item Name: CRF (human, rat) Acetate
Molecular Formula: C208H344N60O63S2
CAS No.: 86784-80-7
Sequence: Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-al-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn- Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2
Item Categories: Peptide;CRF receptor and related
Description of CRF (human, rat) Acetate:
Purity (HPLC)                                 98%min.
Appearance                              White powder
Single Impurity (HPLC)              1.0%max
Amino Acid Composition       ±10% of theoretical
Peptide Content (N%)                 ≥80.0%
Water Content (Karl Fische        ≤6.0%
Acetate Content (HPIC)               ≤15.0%
MS (ESI)                                     Consistent
Mass Balance                             95.0~105.0%

A case report form (or CRF) is a paper or electronic questionnaire specifically used in clinical trial research. The Case Report Form is the tool used by the sponsor of the clinical trial to collect data from each participating site. All data on each patient participating in a clinical trial are held and/or documented in the CRF, including adverse events.

The sponsor of the clinical trial develops the CRF to collect the specific data they need in order to test their hypotheses or answer their research questions. The size of a CRF can range from a handwritten one-time 'snapshot' of a patient's physical condition to hundreds of pages of electronically captured data obtained over a period of weeks or months. (It can also include required check-up visits months after the patient's treatment has stopped.)
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Details of GRF (Human) Acetate

Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF, GHRF), somatoliberin or somatocrinin, is a releasing hormone for growth hormone. It is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus.

GHRH first appears in the human hypothalamus between 18 and 29 weeks of gestation, which corresponds to the start of production of growth hormone and other somatotropes in fetuses.

Item Name: GRF（human）Acetate

Molecular Formula: C215H358N72O66S
CAS No.: 83930-13-6
Sequence:
Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-            Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2

Details of GRF (Human) Acetate:
Purity (HPLC)                                   98%min.
Appearance                                White powder
Single Impurity (HPLC)                1.0%max
Amino Acid Composition             ±10% of theoretical
Peptide Content (N%)                   ≥80.0%
Water Content (Karl Fischer)       ≤6.0%
Acetate Content (HPIC)                  ≤15.0%
MS (ESI)                                        Consistent
Mass Balance                                95.0~105.0%

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Properties of Aviptadil Acetate

Item Name: Aviptadil Acetate
Molecular Formula: C147H238N44O42S
CAS No.: 40077-57-4
Sequence:  His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met- Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Properties of  Aviptadil Acetate:
Purity (HPLC)                                  98%min.
Appearance                                White powder
Single Impurity (HPLC)                 1.0%max
Amino Acid Composition         ±10% of theoretical
Peptide Content (N%)                   ≥80.0%
Water Content (Karl Fischer)       ≤6.0%
Acetate Content (HPIC)                  ≤10.0%
MS (ESI)                                        Consistent
Mass Balance                               95.0~105.0%

Aviptadil (INN) is an analog of vasoactive intestinal polypeptide (VIP) for the treatment of erectile dysfunction. The FDA also recommended that Senetek conduct a two-year rodent study of aviptadil as a result of previously reported brown adipose tissue proliferations observed in the course of a competitor's rodent study in which phentolamine mesylate was administered daily. In August 2000, the MCA lifted the hold on trials stating the findings do not represent a significant carcinogenic risk in man. In October 2000, marketing approval in the UK was granted by the MCA. Regulatory filings in other European countries are underway to seek pan-European approval for aviptadil under the Mutual Recognition Process.

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Specifications of Melanotan I Acetate

Afamelanotide is the International Nonproprietary Name for the molecule [Nle4, D-Phe7]α-MSH [2] initially researched and developed as melanotan-1 and later, CUV1647 [by Clinuvel]. A marketing trade name for one brand of afamelanotide was recently approved by the European Medicines Agency (EMA) Name Review Group (NRG) and the Agency's Committee for Human Medicinal Products (CHMP) as Scenesse (pronounced "sen-esse"). On May 5, 2010 the Italian Medicines Agency (AIFA - Agenzia Italiana del Farmaco) became the first governmental health organization ever (even before the drug received approval in Europe) to authorize afamelanotide as a medicine for therapeutic treatment of Italian citizens to reduce painful photosensitivity stemming from the orphan disease of a "grain of rice" sized bioabsorbable subcutaneous implant as a potential therapeutic photoprotection inducing agent for a series of light related skin indications.

Item Name: MelanotanⅠ Acetate
Molecular Formula: C78H111N21O19
CAS No.: 75921-69-6
Properties of Melanotan I Acetate:
density  1.43
storage temp.  -20°C
solubility  H2O: 5 mg/mL, soluble
form  solid
Specifications of Melanotan I Acetate:
Purity (HPLC)                                        98%min.
Appearance                                        White powder
Single Impurity (HPLC)                      1.0%max
Amino Acid Composition               ±10% of theoretical
Peptide Content (N%)                         ≥80.0%
Water Content (Karl Fischer)             ≤5.0%
Acetate Content (HPIC)                       ≤10.0%
MS (ESI)                                              Consistent
Mass Balance                                     95.0~105.0%
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Description of Ornipressin Acetate

Item Name: Ornipressin Acetate

Molecular Formula: C45H63N13O12S2
CAS No.: 3397-23-7
Item Categories: Amino Acid Derivatives;Peptide
Description of Ornipressin Acetate:
Purity (HPLC)                                         98%min.
Appearance                                    White powder
Single Impurity (HPLC)                      1.0%max
Amino Acid Composition                ±10% of theoretical
Peptide Content (N%)                        ≥80.0%
Water Content (Karl Fischer)           ≤5.0%
Acetate Content (HPIC)                     ≤10.0%
MS (ESI)                                               Consistent
Mass Balance                                   95.0~105.0%

Ornipressin is a vasoconstrictor, haemostatic and renal agent

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Features of Protirelin Acetate

Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF), thyroliberin or protirelin, is a tropic, tripeptidal hormone that stimulates the release of TSH (thyroid-stimulating hormone) and prolactin from the anterior pituitary. TRH has been used clinically for the treatment of spinocerebellar degeneration and disturbance of consciousness in humans.

Item Name    Protirelin Acetate

Molecular Formula     C16H22N6O4
CAS No.    24302-27-9
Features of Protirelin Acetate:
Purity (HPLC)                                                98%min.
Appearance                                               White powder
Single Impurity (HPLC)                              1.0%max
Amino Acid Composition                            ±10% of theoretical
Peptide Content (N%)                                 ≥80.0%
Water Content (Karl Fischer)                     ≤5.0%
Acetate Content (HPIC)                               ≤10.0%
MS (ESI)                                                     Consistent
Mass Balance                                          95.0~105.0%

Protirelin acetate should accumulator at a air-conditioned (2 ~ 8 ℃) & dry abode adequate from light, accumulate amalgamation abutting if not in use.

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Properties of Angiotensin Acetate

Angiotensin is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system. Angiotensin was independently isolated in Indianapolis and Argentina in the late 1930s (as 'angiotonin' and 'hypertensin', respectively) and subsequently characterised and synthesized by groups at the Cleveland Clinic and Ciba laboratories in Basel, Switzerland.

Item Name: Angiotensin Acetate

Molecular Formula: C49H69N13O12

CAS No.: 58-49-1

Properties of Angiotensin Acetate:

Purity (HPLC): 98%min.

Appearance: White powder

Single Impurity (HPLC): 1.0%max

Amino Acid Composition: ±10% of theoretical

Peptide Content (N%): ≥80.0%

Water Content (Karl Fischer): ≤6.0%

Acetate Content (HPIC): ≤10.0%

MS (ESI): Consistent

Mass Balance: 95.0~105.0%

Angiotensinogen is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. It is a member of the serpin family, although it is not known to inhibit other enzymes, unlike most serpins. Plasma angiotensinogen levels are increased by plasma corticosteroid, estrogen, thyroid hormone, and angiotensin II levels.

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Properties of Hexarelin Acetate

Hexarelin (HEX) is a peptide GH secretagogue, structurally similar to GHRP-6,  in the growth factor family which stimulates the release of growth hormone (GH).   It can be used medically to treat GH deficiency. Although relatively new, Hexarelin is becoming a popular choice as a performance enhancement drug. Hexarelin is currently available from several research companies.

Item Name: Hexarelin Acetate

Molecular Formula: C47H58N12O6
CAS No.: 140703-51-1
Sequence: His-2-Me-D-Trp-Ala-Trp-D-Phe-Lys-NH2
Properties of Hexarelin Acetate:
Purity (HPLC)                                     98%min.
Appearance                                    White powder
Single Impurity (HPLC)                    1.0%max
Amino Acid Composition                  ±10% of theoretical
Peptide Content (N%)                       ≥80.0%
Water Content (Karl Fischer)           ≤5.0%
Acetate Content (HPIC)                    ≤10.0%
MS (ESI)                                               Consistent
Mass Balance                                   95.0~105.0%

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Details of Alarelin Acetate

Item Name: Alarelin Acetate

Molecular Formula: C56H78N16O12
CAS No.: 79561-22-1
Item Categories:
Amino Acid Derivatives;Peptide;LH-RH;LH-RHPeptides for Cell Biology; Neuropeptides;Releasing Factors

Description of Alarelin Acetate:
Appearance :White powder
Specific Optical Rotation(c=1,1% HAc) :-47.0~-57.0°
Water Content(Karl Fischer) :≤8.0%
Acetate Content(by HPLC) :≤15.0%
Amino Acid Composition : ±10% of theoretical
Purity(by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) : ≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :≤5EU/mg

An acetate (pronounced /ˈæsɪteɪt/) is a derivative of acetic acid. This term includes salts and esters, as well as the anion found in solution. Most of the approximately 5 billion kilograms of acetic acid produced annually in industry are used in the production of acetates, which usually take the form of polymers. In nature, acetate is the most common building block for biosynthesis. For example, the fatty acids are produced by connecting C2 units derived from acetate.

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Wikipedia's Introduction of Deslorelin Acetate

Deslorelin acetate is an injectable gonadotropin releasing hormone super-agonist (GnRH agonist) also known as an LHRH agonist. It stops the production of sex hormones (testosterone and oestrogen).

Deslorelin Acetate is marketed by Peptech with the brand name Ovuplant. It is currently approved for use in veterinary medicine and is used to induce ovulation in mares as part of the artificial insemination process. It is also used to stabilize high-risk pregnancies, mainly of livestock. Unlike other GnRH agonists, which are mainly used to inhibit luteinizing hormone and follicle-stimulating hormone by their ultimate downregulation of the pituitary gland, Deslorelin is primarily used for the initial flare effect upon the pituitary, and its associated surge of LH secretion.

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Leuprorelin Acetate's Clinical Use

Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl).

An LH-RH (GnRH) analog, leuprolide may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat precocious puberty, and to control ovarian stimulation in In Vitro Fertilization (IVF). It is considered a possible treatment for paraphilias.

Leuprolide has been tested as a treatment for reducing sexual urges in pedophiles and other cases of paraphilia. High doses are sometimes used to chemically castrate sex offenders.

Leuprolide is also under investigation for possible use in the treatment of mild to moderate Alzheimer's disease. Leuprolide is also used to treat chronic adrenal disease in ferrets.[citation needed] It also used for treatment of steroid abuse.

Leuprolide, along with triptorelin and goserelin, are often used to delay puberty in transgender youth until they are old enough to begin hormone replacement therapy.[8] They are also sometimes used as superior alternatives to anti-androgens like spironolactone and cyproterone for suppressing testosterone production in trans women.

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What Is Sermorelin Acetate?

Sermorelin acetate (sermorelin) is the acetate salt of an amidated synthetic 29- amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues. 

Sermorelin acetate is being pushed by a very small number of anti-aging clinics as a "legal" alternative to HGH. A few people are making some claims about why it is better than rHGH, but the claims are all theoretical and not backed by any studies, unlike HGH itself which has numerous studies showing its efficacy.

Sermorelin, sometimes called GRF 1-29, is a growth hormone releasing hormone analogue. It is a 29-amino acid polypeptide representing the 1-29 fragment from endogenous human growth hormone releasing hormone, and is thought to be the shortest fully functional fragment of GHRH. It is used as a test for growth hormone secretion. It is also used as doping substance in sports.

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General Knowledge of Triptorelin Acetate

Item Name: Triptorelin Acetate

Molecular Formula: C64H82N18O13
CAS No.: 57773-63-4
Properties of Triptorelin Acetate:

storage temp.  -20°C
form  powder
Safety Information of Triptorelin Acetate:
Hazard Codes  T
Risk Statements  60
Safety Statements  53-22-36/37/39-45
WGK Germany  3

Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used at the acetate or pamoate salts. By causing constant stimulation of the pituitary, it decreases pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Like other GnRH agonists, triptorelin may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, precocious puberty, estrogen-dependent conditions (such as endometriosis or uterine fibroids), and in assisted reproduction. Triptorelin is marketed under the brand names Decapeptyl (Ipsen) and Diphereline and Gonapeptyl (Ferring Pharmaceuticals). In the United States, it is sold by Watson as Trelstar.In Iran Triptorelin is marketed under the brand name Variopeptyl® 0.1


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Specifications of Desmopressin Acetate

Item Name:   Desmopressin Acetate

Molecular Formula: C46H64N14O12S2
CAS No.:      16789-98-3
Specifications of Desmopressin Acetate:
Appearance :White powder
Specific Optical Rotation (c=1,1% HAc) :-72.0~-82.0°
Water Content(Karl Fischer) :≤6.0%
Acetate Content(by HPLC) :3.0~8.0%
Amino Acid Composition :±10% of theoretical
Purity (by HPLC) :≥98.5%
Single Impurity(by HPLC) :≤0.5%
Peptide Content(by %N) :≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :≤5EU/mg

Desmopressin (trade names: DDAVP, Stimate, Minirin) is a synthetic replacement for vasopressin, the hormone that reduces urine production. It may be taken nasally, intravenously, or as a tablet. Doctors prescribe desmopressin most frequently for treatment of diabetes insipidus, bedwetting or nocturia.

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Description of Lysipressin Acetate

Item Name:      Lysipressin Acetate

Molecular Formula:       C46H65N13O12S2
CAS No.:    50-57-7
Description of Lysipressin Acetate:
Appearance :White powder
Water Content(Karl Fischer) :≤6.0%
Acetate Content(by HPLC) :≤12.0%
Amino Acid Composition :±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) :≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :≤5EU/mg

Acetate esters have the general formula CH3CO2R, where R is an organyl group. The esters are the dominant forms of acetate in the marketplace. Unlike the acetate salts, acetate esters are often liquids, lipophilic, and sometimes volatile. They are popular because they have inoffensive, often sweet odors, they are inexpensive, and they are usually of low toxicity. Acetate is a common anion in biology. It is mainly utilized by organisms in the form of acetyl coenzyme A.


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Description of Terlipressin Acetate

Item Name:     Terlipressin Acetate

Molecular Formula:     C52H74N16O15S2
CAS No.:    14636-12-5
Description of Terlipressin Acetate:

Appearance :White powder
Specific Optical Rotation(c=1,1% HAc) :-95.0~-105.0
Water Content(Karl Fischer) :≤10.0%
Acetate Content(by HPLC) :≤15.0%
Amino Acid Composition :±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) :≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :≤5EU/mg

Terlipressin is currently not available in the United States, or Canada. But is avaliable in much of Europe. Terlipressin (trade names Teripress by New Medicon Pharma and Glypressin by Ferring Pharmaceuticals) is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.


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Description of Thymopentin

Thymopentin, also known as TP-5 is a synthetic derivative of thymopoietin, a thymic hormone, and has immunoregulatory properties. Thymopentin has a molecular formula of C30H49N9O9 

H-Arg-Lys-Asp-Val-Tyr-OH having a Mw of 679.8. It is a kind of sterile filtered white lyophilized (freeze-dried) powder.

[Item Name]      Thymopentin

[Molecular Formula]    C30H49N9O9

[CAS No.]      69558-55-0

Description: Thymopentin is an immunostimulant. It interacts with T cells. It is a thymic polypeptide

Thymopentin is a cellular immune modulating drug, with the induction of T cell differentiation, and promote the development of T lymphocyte subsets, mature and activation function, and can adjust the proportion of various lymphocyte subsets, it tended to be normal.

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Description of Thymosin α1 Acetate

Item Name:     Thymosin α1 Acetate

Molecular Formula:    C129H215N33O55

CAS No.:     62304-98-7

Description of Thymosin α1 Acetate:

Appearance :White powder

Specific Optical Rotation(c=1,15%HAc) :-80.0~-95.0°

Water Content(Karl Fischer) :≤5.0%

Acetate Content(by HPLC) :≤10.0%

Amino Acid Composition :±10% of theoretical

Purity (by HPLC) :≥98.0%

Single Impurity(by HPLC) :≤1.0%

Peptide Content(by N%) :≥82.0%

Assay(By Anhydrous, Acetic Acid-free ) :95.0~102.0%

Bacterial Endotoxins :≤5EU/mg

Thymosin α1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene. Thymosin α1 is believed to be a major component of Thymosin Fraction 5 responsible for the activity of that preparation in restoring immune function in animals lacking thymus glands. It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. Unlike β thymosins, to which it is genetically and chemically unrelated, thymosin α1 is produced as a 28-amino acid fragment, from a longer, 113-amino acid precursor, prothymosin α. It has been found to enhance cell-mediated immunity in humans as well as experimental animals.

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Information About Thymosin β4 Acetate

Item Name:      Thymosin β4 Acetate

Molecular Formula:    C212H350N56O78S

CAS No.:      75591-33-4（net）

Description of Thymosin β4 Acetate:

Purity (HPLC): 95%min.

Appearance White powder

Single Impurity (HPLC) 2.0%max

Amino Acid Composition   ±10% of theoretical

Peptide Content              (N%)≥80.0%

Water Content(Karl Fischer)    ≤5.0%

Acetate Content (HPIC)         ≤15.0%

MS(ESI)              Consistent

Mass Balance         95.0~105.0%

Thymosins are small proteins present in many animal tissues. They are named thymosins because they were originally isolated from the thymus, but most are now known to be present in many other tissues. Thymosins have diverse biological activities, and two in particular, thymosins α1 and β4, have potentially important uses in medicine, some of which have already progressed from the laboratory to the clinic. In relation to diseases, thymosins have been categorized as biological response modifiers.

The archetypical β-thymosin is β4 (product in humans of the TMSB4X gene), which is a major cellular constituent in many tissues. Its intracellular concentration may reach as high as 0.5 mM.[ Following Thymosin α1, β4 was the second of the biologically active peptides from Thymosin Fraction 5 to be completely sequenced and synthesized.

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Simple Information About Bivalirudin Trifluoroacetate

Product Name:  Bivalirudin Trifluoroacetate

Molecular Formula:     C98H138N24O33
CAS No.:     128270-60-0
Description of Bivalirudin Trifluoroacetate:
Appearance :White powder
Water Content(Karl Fischer) :≤5.0%
Trifluoroacetate Content(by HPLC) :≤12.0%
Amino Acid Composition :±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N ) :≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :≤5EU/mg

Trifluoroacetic acid (TFA) is the simplest stable perfluorinated carboxylic acid chemical compound, with the formula CF3CO2H. It is a strong carboxylic acid due to the influence of the electronegative trifluoromethyl group. TFA is almost 100,000-fold more acidic than acetic acid. TFA is widely used in organic chemistry. TFA occurs naturally in sea water, but only in small concentrations (<200 ng/L). Therefore, TFA is prepared industrially by the electrofluorination of acetyl chloride and acetic anhydride.

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