Pharmacology of Medazepam

Medazepam is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.

It is known by the following brand names: Nobrium, Rudotel, Raporan, Ansilan Medazepam is a long acting benzodiazepine drug. The half-life of medazepam is 36 – 200 hours.

Benzodiazepine drugs including medazepam increase the inhibitory processes in the cerebral cortex by allosteric modulation of the GABA receptor. Benzodiazepines may also act via micromolar benzodiazepine binding sites as Ca2+ channel blockers and significantly inhibited depolarization-sensitive calcium uptake in experiments with cell components from rat brains. This has been conjectured as a mechanism for high dose effects against seizures in a study. It has major active benzodiazepine metabolites which gives it a more prolonged therapeutic effects after administration.


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