Human Albumin's Functions

Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver. Albumin constitutes about half of the blood serum protein. It is soluble and monomeric.
Albumin transports hormones, fatty acids, and other compounds, buffers pH, and maintains osmotic pressure, among other functions.

Functions of human albumin:

• Maintains oncotic pressure
• Transports thyroid hormones
• Transports other hormones, in particular, ones that are fat-soluble
• Transports fatty acids ("free" fatty acids) to the liver
• Transports unconjugated bilirubin
• Transports many drugs; serum albumin levels can affect the half-life of drugs
• Competitively binds calcium ions (Ca2+)
• Buffers pH

Serum albumin, as a negative acute-phase protein, is down-regulated in inflammatory states. As such, it is not a valid marker of nutritional status; rather, it is a marker in inflammatory states

Prevents photodegradation of folic acid

Read More: buy Human albumin

Knowledge About Human Immunoglobulin, Intramuscular

Human immunoglobulin does not appear to protect a recipient against hepatitis C. In any case, anti-hepatitis-C-positive blood is excluded from the pool. Where an infection is common, protection is immediate'. For immunisation given intramuscularly at the recommended dosage, antibodies usually remain at protective levels for four to six weeks, and longer for hepatitis A'. Two specific forms of immurioglobulin are prepared - one for intramuscular and the other for intravenous use. The intramuscular form is the more common.

Item name: Human Immunoglobulin, Intramuscular
Specification: 300mg(10% 3ml)/150mg(10% 1.5ml)

Drugs that enter the body by intramuscular injections will be absorbed faster than subcutaneous injections, but slower than intravenous shots. Intramuscular injections may be the best choice, depending on how fast or how gradually the doctor wants the medicine to take effect. The body can hold more fluid inside a muscle than it can retain just under the skin. If the syringe contains a lot of liquid, an intramuscular shot may be the best option.


Read More: Human Immunoglobulin, Intramuscular for sale

An Introduction of Human Tetanus Immunoglobulin

Human tetanus immune globulin (Human Tetanus Immunoglobulin) Department of adsorbed tetanus vaccine in healthy human plasma, were extracted after hepatitis B vaccine made ​​from inactivated virus. Artificial passive immunization of human tetanus immune globulin is injected immediately after an immune effect, but shorter duration of immunity for two weeks, generally not more than three weeks. Generally, it has no adverse reaction after injection. Very few people have swelling, pain, and no special treatment, self-healing.

Specification: 250 IU/vial (100 IU/ml, 2.5ml), 500 IU/vial (100 IU/ml, 5ml)

Description: Human tetanus immunoglobulin is a clear, colorless to pale-yellow sterile preparation of immunoglobulin plasma fraction. It is mainly indicated for the prophylaxis and treatment of tetanus, especially suitable for use in individuals hypersensitive to tetanus antitoxin (TAT).

Read More: Human Tetanus Immunoglobulin for sale

Human Hepatitis B Immunoglobulin's Preparation

Hepatitis B Immune Globulin (Human), Nabi-HB, is a sterile solution of immunoglobulin (5 ± 1% protein)containing antibodies to hepatitis B surface antigen (anti-HBs).  It is prepared from plasma donated by individuals with high titers of anti-HBs.  The plasma is processed using a modified Cohn 6 / Oncley 9 cold-alcohol fractionation process1,2 with two added viral reduction steps described below. Nabi-HB is formulated in 0.042-0.108 M sodium chloride, 0.10-0.20 M glycine, and 0.005-0.050% polysorbate 80, at pH 5.8-6.5.  The product is supplied as a nonturbid sterile liquid in single dose vials and appears as clear to opalescent.  It contains no preservative and is intended for single use by the intramuscular route only.

Hepatitis B immune globulin (HBIG) is a human immune globulin that is used to prevent the development of hepatitis B.

HBIG is prepared from the plasma of donors who have high antibody levels of the hepatitis B surface antigen. It is extracted from the Cohn Fraction II. During the process, viruses are deactivated, and in the final steps, solvents used in the preparation are removed. The preparation is tested for absence of HIV, HCV, herpes virus, and reovirus.


Read More: Human Hepatitis B Immunoglobulin for sale

What Is Human Immunoglobulin (pH4) for Intravenous Injection?

Human immunoglobulin (pH4) for intravenous injection is isolated from normal human plasma by low temperature ethanol extract immune globulin combination of refined through deep processing and virus inactivation steps. It is a complete, has not been modified natural lgG antibodies, up to 98% purity, free of preservatives and antibiotics, specifically for intravenous infusion, compared with intramuscular injection of C-globulin have a role to play fast and significant effect advantages. Human immunoglobulin (pH4) for intravenous injection is a liquid preparation containing human immunoglobulins made from normal human plasma by cold ethanol fractionation method and 5% iso-osmotic glucose including two steps of viral inactivation by pasteurization and low PH method.

Components of human immunoglobulin (pH4) for intravenous injection is made by the hepatitis B vaccination of healthy human plasma through low temperature ethanol extraction, precipitation and then processed to remove the anti-complement activity, and release by the Pap inactivated virus and low PH hatch madedesigned for intravenous infusion of normal immunoglobulin liquid preparation


Read More: buy Human Immunoglobulin (pH4) for Intravenous Injection

What Is Human Prothrombin Complex?

Prothrombin Complex Concentrate (PCC) is a combination of several clotting factors. Prothrombin complex is a double virus–inactivated concentrate, containing equal concentrations of Factors II, VIII, IX, X and Heparin. It is a sterile Filtered White lyophilized (freeze-dried) powder. It is recommended to reconstitute the lyophilized Prothrombin Complex in sterile 18MΩ-cm H2O. Prothrombin-Complex although is stable at room temperature for 3 weeks, it should be stored desiccated below -18°C. Upon reconstitution Prothrombin-Complex should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Human prothrombin complex is a plasma protein fraction containing blood coagulation factor IX together with variable amounts of coagulation factors II.It is used for prevention and treatment of bleeding episodes in patients under warfarin therapy. Octaplex® (Human Prothrombin Complex – Human Coagulation Factor II, VII, IX and X in combination), is a new plasma-derived prothrombin complex concentrate (PCC) which is licensed by Health Canada.  Octaplex® will not require Health Canada’s Special Access Programme authorization.  Octaplex® will be offered lyophilized in a single vial size containing 500 IU of Factor IX to be reconstituted in 20 mL of solvent (provided).

Read More: buy Human Prothrombin Complex

Development of Human Thrombin

Human thrombin allows for the in vitro quantitative determination of human TM concentrations in serum, plasma and other biological fluids.Thrombin is an enzyme resulting from activation of prothrombin, which catalyzes the conversion of fibrinogen to fibrin. It is also a potent stimulus to the aggregation of platelets.

People have developed an aptamer-based microarray for human thrombin detection exploiting two non-overlapping DNA thrombin aptamers recognizing different exosites of the target protein. The 15-mer aptamer binds the fibrinogen-binding site, whereas the 29-mer aptamer  binds the heparin binding domain. Extensive analysis on the complex formation between human thrombin and modified aptamers was performed by Electrophoresis Mobility Shift Assay, in order to verify in solution whether the chemical modifications introduced would affect aptamers/protein recognition. The validated system was then applied to the aptamer microarray, using the solid phase system devised by the solution studies. Finally, the best procedure for Sandwich Aptamer Microarray and the specificity of the sandwich formation for the developed aptasensor for human thrombin were optimized.
Read More: buy Human Thrombin

What Is Human Albumin?

Albumin is the main protein of plasma; it binds water, cations (such as Ca2+, Na+ and K+), fatty acids, hormones, bilirubin, thyroxine (T4) and drugs (including barbiturates) - its main function is to regulate the colloidal osmotic pressure of blood. Alpha-fetoprotein (alpha-fetoglobulin) is a fetal plasma protein that binds various cations, fatty acids and bilirubin. Vitamin D-binding protein binds to vitamin D and its metabolites, as well as to fatty acids. The biological role of afamin (alpha-albumin) has not yet been characterised.
Human serum albumin is the most abundant protein in human blood plasma. It is produced in the liver. Albumin constitutes about half of the blood serum protein. It is soluble and monomeric.
Albumin transports hormones, fatty acids, and other compounds, buffers pH, and maintains osmotic pressure, among other functions.
Albumin is synthesized in the liver as preproalbumin, which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin

Read More: buy Human Albumin

The Use of Human Immunoglobulin-Intramuscular

Intramuscular immunoglobulin may be used as prophylaxis for susceptible contacts if given early in the infection. The optimal timing depends on the disease. The NSW Health Department recommends intramuscular immunoglobulin for the following non-immune contacts of people with hepatitis A as soon as possible, but within two weeks of exposure:

• household or sexual contacts;

• staff and children in an associated day-care centre;

and

• food handlers in an associated catering establishment.

The department recommends intramuscular immunoglobulin for infants (children under one year of age) within six days of first exposure to measles.

Intramuscular immunoglobulin is also useful for:

• travellers to areas endemic for hepatitis A' for whom hepatitis A vaccine is not practicable;

• treatment of patients with abnormal antibody production"; and

• prophylaxis for certain contacts of cases of poliomyelitis, varicella-zoster etc'

Read More: buy Human immunoglobulin, intramuscular

Administrations of Human Tetanus Immunoglobulin

Due to problems with the international supply of plasma, the availability of Human tetanus immunoglobulin (TIG) for prophylaxis is currently extremely limited and supplies of specific TIG are in short supply.  It is not yet clear how long the current situation will last. Human tetanus immunoglobulin is a clear, colourless to pale-yellow sterile preparation of immunoglobulin plasma fraction.It is mainly indicated for the prophylaxis and treatment of tetanus, especially suitable for use in individuals hypersensitive to tetanus antitoxin (TAT).

Human Tetanus Immunoglobulin should be administered via the intramuscular route. If a large volume (> 2mL for children or> 5 mL for adults) is required, it is recommended to administer this in divided doses at different sites. When simultaneous vaccination is necessary, the immunoglobulin and the vaccine should be administered at two different sites.

For prophylaxis, if intramuscular administration is contra-indicated (bleeding disorders), the injection can be administered subcutaneously. However, it should be noted that there are no clinical efficacy data to support administration by the subcutaneous route. For acute therapy, if intramuscular administration is not clinically appropriate, an alternative intravenous product may be used if available.
Read More: buy Human Tetanus Immunoglobulin

Some Information Concerning About Human Immunoglobulin, Intramuscular

The protection afforded is immediate, but is transient and lasts for only a few weeks, as the half-life of IgG, the major constituent, is between 3 and 4 weeks. There are 2 types of immunoglobulin, normal and specific. It is important to recognise that separate immunoglobulin preparations are provided for intramuscular (IM) use and for intravenous (IV) use. These have different properties, and the preparations should be given only by the recommended route. Administration of IM immunoglobulin by the IV route will lead to severe reactions.
An antibody, also known as an immunoglobulin, is a large Y-shaped protein produced by B-cells that is used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, called an antigen. Each tip of the "Y" of an antibody contains a paratope (a structure analogous to a lock) that is specific for one particular epitope (similarly analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for its invasion and survival). The production of antibodies is the main function of the humoral immune system.

Read More: Human Immunoglobulin, Intramuscular for sale

Features of Human Tetanus Immunoglobulin

Human Tetanus Immunoglobulin contains human protein, 40-180 g/L of which at least 95% is IgG. The concentration of specific IgG to tetanus toxin is not less than 100 IU/ml in nominal 250 IU vials. The correct volume to give the stated potency is overprinted on the label.

Human Tetanus Immunoglobulin contains a small quantity of IgA. Individuals who are deficient in IgA have the potential for developing IgA antibodies and may have anaphylactic reactions after administration of blood components containing IgA. The physician must therefore weigh the benefit of treatment with Human tetanus Immunoglobulin against the potential risk of hypersensitivity reactions.

Seldom, human tetanus immunoglobulin may induce a fall in blood pressure with anaphylactic reaction, even in patients who have tolerated previous treatment with human immunoglobulin. Suspicion of allergic or anaphylactic type reactions requires immediate discontinuation of the injection. In case of shock, standard medical treatment for shock should be implemented.

Read More: buy Human Tetanus Immunoglobulin

What Is Human Hepatitis B Immunoglobulin?

The Hepatitis B Immunoglobulin is extracted and isolated through cold ethanol fractionation and virus inactivation from the highly efficient plasma of healthy persons immunized with hepatitis B virus vaccine. The liquid agent of Hepatitis B immunogobulin apparent with slight opalescence is almost colorless or pale yellow. More than 90% protein contained is immunoglobulin. The apparent efficacy of antibody of hepatitis B virus is not less than 100IU/ml. The preparation is indicated for the treatment of shock causes by bleeding, wound of bum, cerebral edema; Intracranial hypertension caused by brain trauma; Byplalbuminemia and edema or ascites caused by cirrhosis or rendl diseases.

Hepatitis B immunoglobulin can only be obtained with a doctor's prescription. Therefore, please discuss with your doctor why it has been prescribed for you and the benefits and risks of this medicine.
Hepatitis B Immune Globulin (Human), Nabi-HB, is a sterile solution of immunoglobulin (5 ± 1%protein) containing antibodies to hepatitis B surface antigen (anti-HBs).  It is prepared from plasma donated by individuals with high titers of anti-HBs.  The plasma is processed using a modified Cohn 6 / Oncley 9 cold-alcohol fractionation process1,2 with two added viral reduction steps described below. Nabi-HB is formulated in 0.042-0.108 M sodium chloride, 0.10-0.20 M glycine, and 0.005-0.050% polysorbate 80, at pH 5.8-6.5.

Read More: Human Hepatitis B Immunoglobulin for sale

Definition of Immunoglobulin

An antibody, also known as an immunoglobulin, is a large Y-shaped protein produced by B-cells that is used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, called an antigen. Each tip of the "Y" of an antibody contains a paratope (a structure analogous to a lock) that is specific for one particular epitope (similarly analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can tag a microbe or an infected cell for attack by other parts of the immune system, or can neutralize its target directly (for example, by blocking a part of a microbe that is essential for its invasion and survival). The production of antibodies is the main function of the humoral immune system.

Antibodies are produced by a type of white blood cell called a plasma cell. Antibodies can occur in two physical forms, a soluble form that is secreted from the cell, and a membrane-bound form that is attached to the surface of a B cell and is referred to as the B cell receptor (BCR). The BCR is only found on the surface of B cells and facilitates the activation of these cells and their subsequent differentiation into either antibody factories called plasma cells, or memory B cells that will survive in the body and remember that same antigen so the B cells can respond faster upon future exposure. In most cases, interaction of the B cell with a T helper cell is necessary to produce full activation of the B cell and, therefore, antibody generation following antigen binding. Soluble antibodies are released into the blood and tissue fluids, as well as many secretions to continue to survey for invading microorganisms.

Read More: buy Human Immunoglobulin (pH4) for Intravenous Injection

Description of Human Prothrombin Complex

Rophylaxis of bleedings in acquired deficiency of the prothrombin complex coagulation factors, such as deficiency caused by treatment with vitamin K antagonists, or in case of overdose of vitamin K antagonists, when rapid correction of the deficiency is required.
Human prothrombin complex is used widely, and for the same indications being sought in this application, although the major local guidelines recommend the concomitant use of FFP in order to provide (in particular) factor VII substrate.

The dosage and duration of Human prothrombin complex therapy depend on the severity of the disorder, on the location and extent of bleeding and on the patient’s clinical condition.  The amount and frequency of administration should be calculated on an individual patient basis.  Dosage intervals must be adapted to the different circulating half-lives of the respective coagulation factors in the prothrombin complex.  The dose will depend on the International Normalised Ratio (INR) before treatment and the targeted INR.
Read More: human prothrombin complex price

Description of Fibrin Sealant

Fibrin sealant can be justified as an alternative to factor concentrates in patients with coagulopathies who have a localized site of bleeding. Newer formulations of fibrinogen and thrombin in a freeze-dried form applied as a bandage may be useful in immediate, on-site treatment of trauma victims in either a civilian or military setting. Fibrin sealant  is a formulation used to create a fibrin clot. It is made up of fibrinogen and thrombin that are injected through one head into the site of a fibrin tear. Fibrin sealant is a type of surgical tissue adhesive derived from human and animal blood products. The ingredients in these sealants interact during application to form a stable clot composed of a blood protein called fibrin. Fibrin sealants are also called fibrin glues.

Read More: buy Surgical Lyophilized Fibrin Sealant, Human

An Introduction of Human Thrombin

Thrombin enzyme (Activated Factor IIa) is an important clotting promoter that controls the transformation of soluble fibrinogen to insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5) that catalyzes many coagulation-related reactions. Thrombin triggers factor-XI, factor-V, Factor-XIII and factor-VIII. Thrombin endorses platelet activation, using activation of protease-activated receptors on the platelet. As a result of its high proteolytic specificity, thrombin has become an important biochemical protein. The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is widely used in linker regions of recombinant fusion protein constructs. After the purification of the fusion protein, thrombin is used to cleave between the Arginine and Glycine residues of the cleavage site, efficiently removing the purification tag from the protein of interest with a high degree of specificity.

This immunoassay kit allows for the in vitro quantitative determination of human TM concentrations in serum, plasma and other biological fluids.Thrombin is an enzyme resulting from activation of prothrombin, which catalyzes the conversion of fibrinogen to fibrin. It is also a potent stimulus to the aggregation of platelets.An

Read More: buy human thrombin

Something One Needs To know Before Using Human Albumin

Some medical conditions may interact with Albumin (Human). If you have any medical conditions, wou should tell your doctor or pharmacist, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
Some MEDICINES MAY INTERACT with Albumin (Human). However, no specific interactions with Albumin (Human) are known at this time.

This may not be a complete list of all interactions that may occur. Please ask your health care provider if Albumin (Human) may interact with other medicines that you take. In addition, you should check with your health care provider before you start, stop, or change the dose of any medicine

Read More: human albumin for sale

Basic Description of Intramuscular

Intramuscular (or IM) injection is the injection of a substance directly into a muscle. In medicine, it is one of several alternative methods for the administration of medications (see route of administration). It is used for particular forms of medication that are administered in small amounts. Depending on the chemical properties of the drug, the medication may either be absorbed fairly quickly or more gradually. Intramuscular injections are often given in the deltoid, vastus lateralis muscles and the ventrogluteal and dorsogluteal areas.

Specification of Intramuscular is 300mg(10% 3ml)/150mg(10% 1.5ml).




Read More: Human Immunoglobulin, Intramuscular price

Understanding of Human Tetanus Immunoglobulin

Human Tetanus Immunoglobulin Ph.Eur. contains human protein, 40-180 g/L of which at least 95% is IgG. The concentration of specific IgG to tetanus toxin is not less than 100 IU/ml in nominal 250 IU vials. The correct volume to give the stated potency is overprinted on the label.

Tetanus is caused by the bacterium Clostridium tetani. If it gets into the body through a wound, it grows and produces a powerful toxin that affects the nervous system (neurotoxin). Symptoms include muscle stiffness and spasms. Human tetanus immunoglobulin  is a medicine which is used in immunisation against or treatment of tetanus.

The information in this Medicine Guide for Tetanus immunoglobulin human varies according to the condition being treated and the particular preparation used.

Read More: buy human tetanus immunoglobulin