Item Name: Thymosin β4 Acetate
Molecular Formula: C212H350N56O78S
CAS No.: 75591-33-4（net）
Description of Thymosin β4 Acetate:
Purity (HPLC): 95%min.
Appearance White powder
Single Impurity (HPLC) 2.0%max
Amino Acid Composition ±10% of theoretical
Peptide Content (N%)≥80.0%
Water Content(Karl Fischer) ≤5.0%
Acetate Content (HPIC) ≤15.0%
MS(ESI) Consistent
Mass Balance 95.0~105.0%
Thymosins are small proteins present in many animal tissues. They are named thymosins because they were originally isolated from the thymus, but most are now known to be present in many other tissues. Thymosins have diverse biological activities, and two in particular, thymosins α1 and β4, have potentially important uses in medicine, some of which have already progressed from the laboratory to the clinic. In relation to diseases, thymosins have been categorized as biological response modifiers.
The archetypical β-thymosin is β4 (product in humans of the TMSB4X gene), which is a major cellular constituent in many tissues. Its intracellular concentration may reach as high as 0.5 mM .[ Following Thymosin α1, β4 was the second of the biologically active peptides from Thymosin Fraction 5 to be completely sequenced and synthesized.
Thymosin β4 is a 43 amino acid peptide which is regarded as the main intracellular G-actin sequestering peptide. Extracellular thymosin β4 may contribute to physiological processes such as angiogenesis, Thymosin β4 Acetate
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