What Is Human Prothrombin Complex?

Prothrombin Complex Concentrate (PCC) is a combination of several clotting factors. Prothrombin complex is a double virus–inactivated concentrate, containing equal concentrations of Factors II, VIII, IX, X and Heparin. It is a sterile Filtered White lyophilized (freeze-dried) powder. It is recommended to reconstitute the lyophilized Prothrombin Complex in sterile 18MΩ-cm H2O. Prothrombin-Complex although is stable at room temperature for 3 weeks, it should be stored desiccated below -18°C. Upon reconstitution Prothrombin-Complex should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Human prothrombin complex is a plasma protein fraction containing blood coagulation factor IX together with variable amounts of coagulation factors II.It is used for prevention and treatment of bleeding episodes in patients under warfarin therapy. Octaplex® (Human Prothrombin Complex – Human Coagulation Factor II, VII, IX and X in combination), is a new plasma-derived prothrombin complex concentrate (PCC) which is licensed by Health Canada.  Octaplex® will not require Health Canada’s Special Access Programme authorization.  Octaplex® will be offered lyophilized in a single vial size containing 500 IU of Factor IX to be reconstituted in 20 mL of solvent (provided).

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