A Statement About Lutrol E

Lutrol E, which is also can be called as Polyethylene glycol (PEG), is widely used as a bowel preparation before surgery.Whole gut lavage with a polyethylene glycol electrolyte solution (PEG) is a common bowel cleansing method for diagnostic and therapeutic colon interventions.

The pharmacological rationale for the use of polyethylene glycol (PEG) in gastroenterology is its inverse relation between molecular mass and intestinal absorbability, with practically no intestinal absorption at molecular masses exceeding 3000, its lack of intestinal enzymatic degradation or bacterial metabolism, and its water binding capacity. PEG is used as a nonabsorbable marker in the evaluation of small intestinal and colonic absorption and secretion, as a marker for intestinal permeability studies, as an essential component of colonic lavage solutions used for the preparation of the colon for diagnostic and therapeutic interventions, and for the treatment of fecal impaction or chronic constipation.
Oral administration of large quantities of polyethylene glycols can have a laxative effect. Therapeutically, up to 4L of an aqueous mixture of electrolytes and high mol wt polyethylene glycol is consumed by patients undergoing bowel cleansing.
In addition, polyethylene glycols are also widely applied in a variety of pharmaceutical formulations. Generally they are regarded as nontoxic and nonirritant materials. Polyethylene glycol 400 has been used on human eyes in an aqueous solution for decontamination after accidents with phenol

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