Triglycidyl isocyanurate is toxic by inhalation and if swallowed. It is a severe eye irritant, and a mild skin and nasal irritant. Both pure TGIC, and TGIC-containing powder coatings have the potential to cause skin sensitisation in people which can lead to severe skin rashes. The effects of repeated long-term exposure to TGIC have not been well studied, but kidney damage has been observed in rats repeatedly exposed to TGIC by oral dosing, and damage to the developing sperm cells has been observed in mice repeatedly exposed to TGIC orally and by inhalation. There is animal evidence that exposure of males to TGIC produces genetic changes in the sperm which may lead to heritable effects in the offspring. There is cause for concern that these effects could occur in humans, so that TGIC has been classified in the EU as a Category 2 mutagen. The reproductive toxicity of TGIC has not been well studied. Information on the health effects of TGIC is published in HSE guidance Note EH64 (1997 supplement).
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