General Idea of CRH(Corticotropin Releasing Hormone)

Corticotropin-releasing hormone (CRH), originally named corticotropin-releasing factor (CRF), and also called corticoliberin, is a polypeptide hormone and neurotransmitter involved in the stress response. Corticotropin-releasing hormone is a hormone made by the hypothalamus that stimulates the release of corticotropin by the anterior pituitary gland. Corticotropin-releasing hormone is abbreviated and often referred to as CRH.

CRH is chemically classed as a neuropeptide hormone -a protein-like molecule made up of a short chain of amino acids produced in the brain that functions as a hormone. The anterior pituitary where CRH acts is the front portion of the pituitary, a small gland in the head. It secretes hormones that influence growth, sexual development, skin pigmentation, thyroid function, and the function of the adrenal cortex.

CRH is always released by the mother and the embryo soon after the embryo implants in the uterus. The function of the CRH appears to protect the embryo from immunologic rejection by the mother. Without CRH, the embryo may be rejected by the mother, resulting in a miscarriage

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