Function of Secretin Acetate

Information of Secretin Acetate:

CAS Number: 17034-35-4

Molecular Weight: 3055.47

Molecules Formula: C130H220N44O41

Secretin can increase watery bicarbonate solution from pancreatic and bile duct epithelium. Pancreatic centroacinar cells have secretin receptors in their plasma membrane. As secretin binds to these receptors, it stimulates adenylate cyclase activity and converts ATP to cyclic AMP. Cyclic AMP acts as second messenger in intracellular signal transduction and leads to increase in release of watery carbonate.It is known to promote the normal growth and maintenance of the pancreas.

Secretin can also increase water and bicarbonate secretion from duodenal Brunner's glands in order to buffer the incoming protons of the acidic chyme. It also enhances the effects of cholecystokinin to induce the secretion of digestive enzymes and bile from pancreas and gallbladder, respectively.
It counteracts blood glucose concentration spikes by triggering increased insulin release from pancreas, following oral glucose intake.
Although secretin releases gastrin from gastrinomas, it inhibits gastrin release from the normal stomach. It reduces acid secretion from the stomach by inhibiting gastrin release from G cells.:844 This helps neutralize the pH of the digestive products entering the duodenum from the stomach, as digestive enzymes from the pancreas (e.g., pancreatic amylase and pancreatic lipase) function optimally at slightly basic pH. In addition, secretin stimulates pepsin secretion from chief cells, which can help break down proteins in food digestion. It also stimulates release of glucagon, pancreatic polypeptide and somatostatin.

Read More:  Secretin Acetate suppliers