Lutrol F127 is soluble in water, ethanol (95%) and isopropanol. It is insoluble in ether, paraffn and fatty oils. Fields of application Lutrol F127 is used primarily as a thickening agent and gel former, but also as a co-emulsifer and consistency enhancer in creams and liquid emulsions. It is also used as a solubilizer for certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical and cosmetic formulations.
Moreover, Lutrol F 127 is suitable for the formulation of active substances that show reduced solubility as a result of neutralization. Owing to its ability to affect viscosity, Lutrol F 127 is suitable as a stabilizer for topically and orally administered suspensions. Lutrol F 127 is also used in toothpastes, gargles and mouthwashes. Preparation of gels Gels may generally be prepared by two methods:
1. “Cold process”
Lutrol F 127 is dissolved completely in water at room temperature or water
pre-cooled to approx. 5°C. Active substances that are insoluble in water
are dissolved in ethanol, isopropanol or propylene glycol and mixed with the
aqueous phase at 5°C to form a homogeneous mass.
2. “Hot process”
Lutrol F 127 is dissolved in water at approx. 70°C. Active substances that are
insoluble in water are dissolved in ethanol, isopropanol or propylene glycol at
70°C and mixed with the warm aqueous phase to form a homogeneous mass.
The gel forms when the solution cools to room temperature.
No comments:
Post a Comment