Description of Human Prothrombin Complex

Rophylaxis of bleedings in acquired deficiency of the prothrombin complex coagulation factors, such as deficiency caused by treatment with vitamin K antagonists, or in case of overdose of vitamin K antagonists, when rapid correction of the deficiency is required.
Human prothrombin complex is used widely, and for the same indications being sought in this application, although the major local guidelines recommend the concomitant use of FFP in order to provide (in particular) factor VII substrate.

The dosage and duration of Human prothrombin complex therapy depend on the severity of the disorder, on the location and extent of bleeding and on the patient’s clinical condition.  The amount and frequency of administration should be calculated on an individual patient basis.  Dosage intervals must be adapted to the different circulating half-lives of the respective coagulation factors in the prothrombin complex.  The dose will depend on the International Normalised Ratio (INR) before treatment and the targeted INR.
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