150 polymyxin B and colistin indications?

Polymyxin B and slime molds, known as a similar antibacterial spectrum antibacterial strength only slightly different, the antimicrobial spectrum of a narrow, clinical application is limited to gram-negative bacterial infection in the past few polymyxin treatment of Pseudomonas aeruginosa infectionthe main drug in recent years, aminoglycoside antibiotics, semi-synthetic broad-spectrum penicillin and the third and fourth generation cephalosporins such as the rapid development of multi-application of polymyxin has been limited. However, due to higher antibacterial activity of polymyxin, bacteria rarely its develop resistance to polymyxin class drugs, so when the bacteria resistant to these drugs or poor efficacy of these drugs, you can still choose. Polymyxin for the treatment of Pseudomonas aeruginosa sepsis combined with carbenicillin, gentamicin, tetracycline, sulfa drugs, if necessary.
Pseudomonas aeruginosa infection of burn wound should be injection and local joint administration. Polymyxin B intramuscularly in the urine because of their higher concentration to maintain a longer time, due to Pseudomonas aeruginosa urinary tract infection by E. coli, Klebsiella pneumoniae urinary tract infection can be applied to other antibiotic resistance polymyxin, is expected to achieve good results. Pseudomonas aeruginosa meningitis can be used polymyxin B sulfate for intrathecal injection.

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