Research Progress of Anti-Defensin β1

Anti-defensin β1 as a kind of antimicrobial peptides, a class of arginine-rich cationic low molecular weight peptide, is widely distributed in animals, plants and insects. Antibacterial tests showed that the strong anti-defensin on Gram-positive and-negative bacteria, fungi, mycobacteria, spirochetes, Phi membrane viruses and other pathogenic microorganisms, even on the mycoplasma, chlamydia, spirochetes and malignant cells (eg tumor cells) and HIV in vitro. The use of genetic engineering techniques to express the mass production of toxic side effects of defensins, nor will the strain variation of pathogenic microorganisms resistant to, and has a broad resistance spectrum.

Various types of biological nature have inherent defense system. The study found that many of the in vivo existence of a class of short-chain peptides with antibacterial effect, collectively known as antimicrobial peptides. Biological organisms the synthesis of endogenous antimicrobial peptides with broad-spectrum, highly effective anti-microbial activity, is an important component of the innate immune system. Mammalian antimicrobial peptides divided into two categories: the defensins (defensins) and cathelicidins. The former containing six conserved cysteines, forming three intramolecular disulfide bonds, while the latter contains a conserved cathelin region, the formation of the structure of different antimicrobial peptides. The defensin include alpha-defensins produced by Paneth cells and β-defensins produced by the intestinal epithelial cells. Anti-defensin β1 cationic peptides with broad-spectrum antimicrobial activity, is a product of the epithelial cells and leukocytes.
Anti-defensin β1 should be store at -20 °. It means that anti-defensin β1 should be stored at low temperatures, and be prolonged exposure to the air, the content will be reduced.

 

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