The genome sequence of Bifid bacterium longed reflects its adaptation to the human gastrointestinal tract

Bifid bacteria are gram-positive prokaryotes that naturally colonize the human gastrointestinal tract (GIT) and vagina. Although not numerically dominant in the complex intestinal micro flora, it is seen as key commensalisms that included promoting a healthy GIT. We determined the 2.26 Mb genome sequence of an infant-derived strain of Bifid bacterium longed, and identified 1,730 possible coding sequences organized in a 60%-GC circular chromosome. A bioinformatics analysis revealed could some physiological characteristics that help to explain the successful adaptation of these bacteria in the colon. An unexpectedly large number of predicted proteins appeared to catabolism of a variety of oligosaccharides, some possibly by rare or novel glucose hydrolyses, which have specialized in "no digestible" plant polymers or host-derived glycoprotein’s and glycoconjugates released. This ability to absorb nutrients from a variety of likely contributes to the competitiveness and persistence of bifid bacteria in the colon. Many genes that were in the metabolism of oligosaccharides in self-regulated modules that have arisen in part from gene duplication or horizontal acquisition appear to be found. Complete pathways for all amino acids, nucleotides, and some key vitamins were identified, however, were routes for Asp-Cays and atypical. More importantly, genome analysis provided insights into the reciprocal interactions of bifid bacteria with their hosts asked. We identified polypeptides that are homologous to proteins most important for the production of glycoprotein-binding imbricate, structures that could potentially apply to the liability and persistence in the GIT was important needs. We also found a eukaryotic-type serine protease inhibitor (seeping) possibly in the reported immunomodulatory activity of bifid bacteria involved.

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