summary
Acute diarrhea is a serious cause of infant morbidity and mortality and the development of preventive measures remains an important goal. Bifidobacteria (which constitute the predominant intestinal flora of breast-fed infants), as well as other lactic acid-producing organisms such as Streptococcus thermophilus, are thought to have a protective effect against acute diarrheal diseases. However, their efficacy is not in controlled studies have been investigated.
In a double-blind, placebo-controlled study, children aged 5-24 months who were admitted to a chronic medical care hospital were randomized to receive a standard infant formula or the same formula with Bifidobacterium bifidum and S. thermophilus supplemented receive. Patients were evaluated daily for the occurrence of diarrhea and fecal samples were obtained weekly for rotavirus antigen assayed by enzyme immunoassay. Fecal samples were obtained during an episode of diarrhea for virological and bacteriological analyzes. 55 patients were evaluated for a total of 4447 patient-days during 17 months. 8 (31%) of the 26 patients receiving the control formula and 2 (7%) of 29 completed, the developed formula, diarrhea during the study (p = 0.035, Fisher's exact test, two-tailed) received. 10 (39%) of subjects who received the control formula and 3 (10%) of those who received the supplemented formula shed rotavirus at some time during the study (p = 0.025). Supplementation of infant formula with B bifidum and S thermophilus can reduce the incidence of admitted acute diarrhea and rotavirus excretion in infants in hospitals.
Acute diarrhea is a serious cause of infant morbidity and mortality and the development of preventive measures remains an important goal. Bifidobacteria (which constitute the predominant intestinal flora of breast-fed infants), as well as other lactic acid-producing organisms such as Streptococcus thermophilus, are thought to have a protective effect against acute diarrheal diseases. However, their efficacy is not in controlled studies have been investigated.
In a double-blind, placebo-controlled study, children aged 5-24 months who were admitted to a chronic medical care hospital were randomized to receive a standard infant formula or the same formula with Bifidobacterium bifidum and S. thermophilus supplemented receive. Patients were evaluated daily for the occurrence of diarrhea and fecal samples were obtained weekly for rotavirus antigen assayed by enzyme immunoassay. Fecal samples were obtained during an episode of diarrhea for virological and bacteriological analyzes. 55 patients were evaluated for a total of 4447 patient-days during 17 months. 8 (31%) of the 26 patients receiving the control formula and 2 (7%) of 29 completed, the developed formula, diarrhea during the study (p = 0.035, Fisher's exact test, two-tailed) received. 10 (39%) of subjects who received the control formula and 3 (10%) of those who received the supplemented formula shed rotavirus at some time during the study (p = 0.025). Supplementation of infant formula with B bifidum and S thermophilus can reduce the incidence of admitted acute diarrhea and rotavirus excretion in infants in hospitals.
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