Simple Introduction of DCP (Des-γ-Carboxy-Prothrombin)

Des-gamma carboxyprothrombin (DCP), also known as protein induced by vitamin K absence/antagonist-II (PIVKA-II), is an abnormal form of the coagulation protein, prothrombin. Normally, the prothrombin precursor undergoes post-translational carboxylation (addition of a carboxylic acid group) by gamma-glutamyl carboxylase in the liver prior to secretion into plasma. DCP/PIVKA-II may be detected in people with deficiency of vitamin K (due to poor nutrition or malabsorption) and in those taking warfarin or other medication that inhibits the action of vitamin K.

Desgamma-carboxy prothrombin (DCP), has been reported to be useful in the diagnosis of HCC. This marker is also known as a protein induced by vitamin K absence or antagonist-II (PIVKA-II) or abnormal prothrombin.

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