Protamine Sulfate ,protamines injection, is a sterile, non-pyrogenic, isotonic solution of protamine sulfate protamine in water for injection. It works as a heparin antagonist. It is also a weak anticoagulant.Protamines are simple protein principles obtained from the sperm of salmon and certain other species of fish. Protamines have low molecular weight, are rich in arginine, and are strongly basic.
Protamine sulfate protamines occurs as fine white or off-white amorphous or crystalline powder. It is sparingly soluble in water. The pH is between 6 and 7. The cationic hydrogenated protamine at a pH of 6.8 to 7.1 reacts with anionic heparin at a pH of 5.0 to 7.5 to form an inactive complex.
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