How Thrombin Work?

 Thrombin is a trypsin-like serine protease protein, encoded by the F2 gene in human. The proteins are cleaved prothrombin (coagulation factor II) to form the first step of thrombin in the coagulation cascade, and ultimately in the loss of blood caused results. In turn it acts as a serine protease, soluble fibrinogen into insoluble fibrin, silk and catalyze many other related clotting reactions of thrombin.Thrombin bound to thrombomodulin protein to activated protein C, coagulation cascade inhibitors. After the thrombomodulin and endothelial cells to express an integral membrane protein binding of thrombin to activated protein C is greatly enhanced. Activated protein C inactivated factor, VA and VIIIA.

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Thrombin enzyme (activating factor IIA) is an important coagulation promoter control of soluble fibrinogen into insoluble active fibrin strands. Thrombin is a coagulation protein and a serine protease (EC 3.4.21.5), a catalyst for a number of the clotting reaction.