Leuprorelin (INN) or leuprolide acetate (USAN) is a GnRH analog. Proper Sequence: Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt (Pyr = L-Pyroglutamyl).
An LH-RH (GnRH) analog, leuprolide may be used in the treatment of hormone-responsive cancers such as prostate cancer or breast cancer, estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat precocious puberty, and to control ovarian stimulation in In Vitro Fertilization (IVF). It is considered a possible treatment for paraphilias.
Leuprolide has been tested as a treatment for reducing sexual urges in pedophiles and other cases of paraphilia. High doses are sometimes used to chemically castrate sex offenders.
Leuprolide is also under investigation for possible use in the treatment of mild to moderate Alzheimer's disease. Leuprolide is also used to treat chronic adrenal disease in ferrets.[citation needed] It also used for treatment of steroid abuse.
Leuprolide, along with triptorelin and goserelin, are often used to delay puberty in transgender youth until they are old enough to begin hormone replacement therapy.[8] They are also sometimes used as superior alternatives to anti-androgens like spironolactone and cyproterone for suppressing testosterone production in trans women.
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