Item Name: Thymosin α1 Acetate
Molecular Formula: C129H215N33O55
CAS No.: 62304-98-7
Description of Thymosin α1 Acetate:
Appearance :White powder
Specific Optical Rotation(c=1,15%HAc) :-80.0~-95.0°
Water Content(Karl Fischer) :≤5.0%
Acetate Content(by HPLC) :≤10.0%
Amino Acid Composition :±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by N%) :≥82.0%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~102.0%
Bacterial Endotoxins :≤5EU/mg
Thymosin α1 is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene. Thymosin α1 is believed to be a major component of Thymosin Fraction 5 responsible for the activity of that preparation in restoring immune function in animals lacking thymus glands. It was the first of the peptides from Thymosin Fraction 5 to be completely sequenced and synthesized. Unlike β thymosins, to which it is genetically and chemically unrelated, thymosin α1 is produced as a 28-amino acid fragment, from a longer, 113-amino acid precursor, prothymosin α. It has been found to enhance cell-mediated immunity in humans as well as experimental animals.
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