Thursday, May 3, 2012

Description of Terlipressin Acetate


Terlipressin AcetateItem Name:     Terlipressin Acetate
Molecular Formula:     C52H74N16O15S2
CAS No.:    14636-12-5
Description of Terlipressin Acetate:
Appearance :White powder
Specific Optical Rotation(c=1,1% HAc) :-95.0~-105.0
Water Content(Karl Fischer) :≤10.0%
Acetate Content(by HPLC) :≤15.0%
Amino Acid Composition :±10% of theoretical
Purity (by HPLC) :≥98.0%
Single Impurity(by HPLC) :≤1.0%
Peptide Content(by %N) :≥80%
Assay(By Anhydrous, Acetic Acid-free ) :95.0~105.0%
Bacterial Endotoxins :≤5EU/mg

Terlipressin is currently not available in the United States, or Canada. But is avaliable in much of Europe. Terlipressin (trade names Teripress by New Medicon Pharma and Glypressin by Ferring Pharmaceuticals) is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.


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