Bacitracin History

The drug's unique name derives from the fact that it was isolated by John T. Goorley from a girl named Tracy:
One strain isolated from tissue debrided from a compound fracture of the tibia was particularly active. We named this growth-antagonistic strain for the patient, "Tracy I." When cell-free filtrates of broth cultures of this bacillus proved to possess strong antibiotic activity and to be non-toxic, further study seemed warranted. We have called this active principle "Bacitracin." It was approved by FDA in 1948.Synthesis
Bacitracin is synthesised via what is called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis.bacABC is involved in synthesis.
Main article: Bactoprenol phosphate
Bacitracin interferes with the dephosphorylation of the C55-isoprenyl pyrophosphate, a molecule that carries the building-blocks of the peptidoglycan bacterial cell wall outside of the inner membrane.
Bacitracin has been claimed to be a protein disulfide isomerase inhibitor in cells, but this is disputed by in vitro studies.
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