Vinyl fluoride is an organic halide with the chemical formula C2H3F. It is a colorless gas with a faint etherlike odor. It is used as the monomeric precursor to the fluoropolymer polyvinylfluoride.
Vinyl fluoride (VF) is reasonably anticipated to be a human carcinogen based on evidence of tumor induction at multiple organ sites in rats and mice. Inhalation exposure of rats to vinyl fluoride resulted in increased incidences of hepatic hemangiosarcomas, hepatocellular adenomas or carcinomas, and Zymbal gland carcinomas; inhalation exposure of mice to VF resulted in increased incidences of hepatic hemangiosarcomas, bronchiolar-alveolar adenomas or adenocarcinomas, hepatocellular adenomas, mammary gland adenocarcinomas, and Harderian gland adenomas (Bogdanffy et al. 1995; IARC 1995). The tumor response to VF in laboratory animals is similar to the responses to vinyl chloride, a known human carcinogen (NTP 1998; IARC 1987), and to vinyl bromide, a probable human carcinogen (IARC 1986). A unique feature of vinyl chloride carcinogenicity is the induction of rare hepatic hemangiosarcomas in rats and mice and the causal association in epidemiological studies between vinyl chloride exposure and excess risk of hemangiosarcoma of the liver (NTP 1998). The fact that VF, vinyl chloride, and vinyl bromide induce rare hemangiosarcomas of the liver in experimental animals and induce the formation of similar DNA adducts suggests a possible common mechanism of carcinogenicity for these vinyl halides.a colorless gas at ambient temperature and pressure and is highly flammable. VF is used in the production of polyvinyl fluoride and other fluoropolymers and as an intermediate in organic synthesis.
Read More: Vinyl fluoride price
No comments:
Post a Comment