Tuesday, May 1, 2012

Contraindications of Chlordiazepoxide

Chlordiazepoxide
Use of chlordiazepoxide should be avoided in individuals with the following conditions:

ž            Myasthenia gravis
ž            Acute intoxication with alcohol, narcotics, or other psychoactive substances
ž            Ataxia
ž            Severe hypoventilation
ž            Acute narrow-angle glaucoma
ž            Severe liver deficiencies (hepatitis and liver cirrhosis decrease elimination by a factor of 2)
ž            Severe sleep apnea
Hypersensitivity or allergy to any drug in the benzodiazepine class
Chlordiazepoxide is generally considered an inappropriate benzodiazepine for the elderly due to its long elimination half-life and the risks of accumulation. Benzodiazepines require special precaution if used in the elderly, pregnancy, children, alcohol- or drug-dependent individuals and individuals with comorbid psychiatric disorders.

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