Target of rapamycin as a novel antitumor target

In mammals, target of rapamycin is best known to regulate translation through the ribosomal protein S6 kinases (S6Ks) and the eukaryotic translation initiation factor 4E-binding proteins. Consistent with the contribution of translation to growth, target of rapamycin regulates cell,
organ, and organismal size. The identification of the tumor suppressor proteins tuberous sclerosis1 and 2 (TSC1 and 2) and Ras-homolog enriched in brain (Rheb) has biochemically linked the target of rapamycin and phosphatidylinositol 3-kinase (PI3K) pathways, providing a mechanism for
the crosstalk that occurs between these pathways. Target of rapamycin is emerging as a novel antitumor target, since the target of rapamycin inhibitor rapamycin appears to be effective against tumorsresulting from aberrantly high PI3K signaling.

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