Geldanamycin brief introduction

Geldanamycin (GA) is a natural product produced by Streptomyces hygroscopicus. InvivoGen producesGeldanamycin   from amutant strain of S. hygroscopicus, inactivated for the synthesis of nigericin, a common contaminant of Geldanamycin .  Geldanamycin binds with high affinity into the ATP binding pocket of Hsp90. Hsp90 is a ubiquitous molecular chaperone critical for the folding, assembly and activity of multiple mutated and overexpressed signaling proteins that promote the growth and / or survival of tumor cells. Hsp90 client proteins include mutated p53, Raf-1, Akt, ErbB2 and hypoxia- inducible factor 1a (HIF-1a). Binding of  Geldanamycin to Hsp90 causes the destabilization and degradation of its client proteinsRead more;http://www.acid-lactic-bacteria.com/bulk-drug/Geldanamycin/