Item Name: Cloprostenol
Molecular Formula:C27H46NaO
CAS No.: 55028-72-3
Item Description:
Cloprostenol is a synthetic prostaglandin analogue of F2α for use in cattel, horses, and pigs.
CAS No.: 55028-72-3
Item Description:
Cloprostenol is a synthetic prostaglandin analogue of F2α for use in cattel, horses, and pigs.
Cloprostenol is a functional analogue of prostaglandin F2α having a specific luteolytic action. It causes functional and morphological regression of the corpus luteum (luteolysis) in cattles and horses followed by return to oestrus and normal ovulation.
(+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol accountable for the majority of its biological activity. Cloprostenol is 200 times and 100 times more potent than PGF2α in terminating pregnancy in hamsters and rats, respectively without the side effects associated with PGF2α. The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively. Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10-12 M.
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