Information of P-methoxycinnamic Acid

Item Name: P-methoxycinnamic acid        

Molecular Formula: C10H10O3

CAS No.: 830-09-1

Synonyms:

• 4-Methoxycinnamic acid,predominantly trans;
• p-Methoxy Cinnamic Acid(trans);
• 4-Methoxycinnamic acid;
• 3-(4-methoxyphenyl)acrylic acid;
• (2E)-3-(4-methoxyphenyl)prop-2-enoic acid

Normally, the bromination of alkenes only result in the anti addition of molecular bromine. However, bromination of p-methoxycinnamic acid results in both syn and anti addition.

People investigated the chemopreventive effect of p-methoxycinnamicacid (p-MCA), an active phenolic acid of rice bran, turmeric, and Kaemperfia galanga against 1,2-dimethylhydrazine-induced rat colon carcinogenesis. Male albino Wistar rats were randomly divided into six groups. Group 1 consisted of control rats that received a modified pellet diet and 0.1% carboxymethyl cellulose. The rats in Group 2 received a modified pellet diet supplemented with p-MCA [80 mg/kg body weight (b.wt.) post-orally (p.o.)] everyday. The rats in Groups 3–6 received 1,2-dimethylhydrazine (DMH) (20 mg/kg b.wt.) via subcutaneous injections once a week for the first 4 weeks; additionally, the rats in Groups 4, 5 and 6 received p-MCA at doses of 20, 40 and 80 mg/kg b.wt./day p.o., respectively, everyday for 16 weeks.

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