Tuesday, May 15, 2012

Description of 17a-Hydroxyprogesterone Acetate


CAS: 302-23-8
Molecular Formula: C23H32O4
Molecular Weight: 372.5 g/mol
Specification: Enterprise standard
17a-Hydroxyprogesterone acetate is product is white crystal powder with its melting point 249-250°C and boiling point 490.2 ° C at 760 mmHg .The specification is  not less than 98%.It can be used for intermediate of steroid hormone drug.

Measurements of levels of 17-hydroxyprogesterone are useful in the evaluation of patients with suspected congenital adrenal hyperplasia as the typical enzymes that are defective, namely 21-hydroxylase and 11β-hydroxylase, lead to a build-up of 17OHP. In contrast, the rare patient with 17α-hydroxylase deficiency will have very low or undetectable levels of 17OHP. 17OHP levels can also be used to measure contribution of progestational activity of the corpus luteum during pregnancy as progesterone but not 17OHP is also contributed by the placenta.

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