Rapamycin Profile

Sirolimus (Rapamycin, RAPA, RPM), also known as Sirolimus is a macrolide antibiotic, can be used for low-dose hormone and F rapamycin the treatment FSGSK506 structurally similar. Rapamycin was initially to study as a low-toxicity antifungal rapamycin has immunosuppressive effects, 1989, rapamycin as a treatment of organ transplant rejection drug trial in 1977 found that, at present (2010), rapamycinthe I and Phase II clinical trial has ended, phase III clinical trials are ongoing. Formula of rapamycin for C51H79NO13 991KD molecular weight, as a white crystalline solid, melting point 183-185 ℃, lipophilic, dissolved in organic solvents such as methanol, ethanol, acetone, chloroform, very slightly soluble in water, almost insoluble in ether. Effect from animal experiments and clinical application of rapamycin is an effective, low toxicity, renal toxicity of a new immunosuppressant.
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