Some Knowledge of 2-Cyclohexen-1-One

Item name: 2-cyclohexen-1-one

CAS No.: 930-68-7
Molecular formula: C6H8O
Molecular weight: 96.13
Purity(HPLC): 97%min (GC)
Appearance: Colorless liquid

Cyclohexen (1,2,3,4-Tetrahydrobenzol) ist eine farblose Flüssigkeit mit der Summenformel C6H10. Sie gehört zu den Cycloalkenen (cyclische Kohlenwasserstoffe mit mindestens einer Doppelbindung).

Glutathione is able to protect membrane proteins from oxidative stress. In ischemia/reperfusion injury, free radicals cause synaptosomal membrane protein and lipid oxidation that is prevented by the free radical scavenger N-tert-butyl-alpha-phenylnitrone (Hall N. C. et al. (1995) Neuroscience 64, 81-89; 69, 591-600). We wondered if diminution of glutathione would lead to further membrane alterations. Accordingly, the effects of glutathione depletion, by intraperitoneal administration of 2-cyclohexene-1-one, on the physical state of cortical synaptosomal membrane proteins and lipids, with and without global ischemia/reperfusion, were studied in vivo and in vitro in adult and aged gerbils utilizing electron paramagnetic resonance spectrometry. 2-Cyclohexene-1-one (100 mg/kg, i.p.) was administered 30 min prior to 10-min ischemia followed by 1 or 14 h reperfusion.

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