Wednesday, June 6, 2012

Instructions for Uses of Lead Ingot

Ingots require a second procedure of shaping, such as cold/hot working, cutting or milling to produce a useful final product. Additionally ingots (of less common materials) can be used as currency, or as a currency reserve as with gold bars.

lead ingotLead is used in building construction, lead-acid batteries, bullets and shots, weights, as part of solders, pewters, fusible alloys and as a radiation shield. Lead has the highest atomic number of all of the stable elements, although the next higher element, bismuth, has a half-life that is so long (much longer than the age of the universe) that it can be considered stable. Its four stable isotopes have 82 protons, a magic number in the nuclear shell model of atomic nuclei.

Item name:  lead ingot
Application:  used for manufacturing lead batteries, lead-based alloy, cable coating, plumbing and lining equipment, radioactive and ray protective layer, etc.
The technical standard:   (GB/T469-2005)

Instructions for Uses of Lead Ingot:
Lead ingots should avoid acid and alkali corrosion and rain, so as to avoid product contamination should be removed before using the dust and debris in the surface

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Simple Introduction of High Purity Vc


Item Name: High purity Vc
Properties:
Appearance: translucenmt viscous liquid
Color: coffee color
Contents(Vc):>10%
PH(6%,20℃): 3-4
viscocity: 7300-9300

Vitamin C or L-ascorbic acid or L-ascorbate is an essential nutrient for humans and certain other animal species. In living organisms ascorbate acts as an antioxidant by protecting the body against oxidative stress. It is also a cofactor in at least eight enzymatic reactions including several collagen synthesis reactions that, when dysfunctional, cause the most severe symptoms of scurvy. In animals these reactions are especially important in wound-healing and in preventing bleeding from capillaries.

Ascorbate (an ion of ascorbic acid) is required for a range of essential metabolic reactions in all animals and plants. It is made internally by almost all organisms although notable mammalian group exceptions are most or all of the order chiroptera (bats), guinea pigs, capybaras, and one of the two major primate suborders, the Anthropoidea (Haplorrhini) (tarsiers, monkeys and apes, including human beings). Ascorbic acid is also not synthesized by some species of birds and fish. All species that do not synthesize ascorbate require it in the diet. Deficiency in this vitamin causes the disease scurvy in humans. It is also widely used as a food additive.

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General Introduction of Aluminum Section

Aluminum section

Item Name: Aluminum section
Features: Appearance of the light, the original column. Application of thin-walled parts with aluminum and zinc or cast surface spray treatment on the surface has significant growth effect.
Uses: Mainly used in valves, electrical parts, accessories and other parts of the finishing, strengthening, matt, hyperchromic and other surface processing.
Aluminum is an abundant metallic chemical element which is widely used throughout the world for a wide range of products. Many consumers interact with some form of it on a daily basis, especially if they are active in the kitchen. The element has an atomic number of 13, and it is identified with the symbol Al on the periodic table of elements. It is classified in the poor metals, sharing the property of extreme malleability with metals like tin and lead. The international standard spelling is aluminium.

Aluminium or aluminum is a silvery white member of the boron group of chemical elements. It has the symbol Al, and its atomic number is 13. It is not soluble in water under normal circumstances.

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What Is Ferro Niobium?

Cargo Name: Ferro Niobium
Packing: IN 250KGSTEEL DRUMS
Danger Grade: General Cargo
 Ferro Niobium Niobium, ny-OH-bee-əm or columbium (/kəˈlʌmbiəm/ kə-LUM-bee-əm), is a chemical element with the symbol Nb and atomic number 41. It is a soft, grey, ductile transition metal, which is often found in the pyrochlore mineral, the main commercial source for niobium, and columbite. The name comes from Greek mythology: Niobe, daughter of Tantalus.

Niobium has physical and chemical properties similar to those of the element tantalum, and the two are therefore difficult to distinguish. The English chemist Charles Hatchett reported a new element similar to tantalum in 1801 and named it columbium. In 1809, the English chemist William Hyde Wollaston wrongly concluded that tantalum and columbium were identical. The German chemist Heinrich Rose determined in 1846 that tantalum ores contain a second element, which he named niobium. In 1864 and 1865, a series of scientific findings clarified that niobium and columbium were the same element (as distinguished from tantalum), and for a century both names were used interchangeably. The name of the element was officially adopted as niobium in 1949.

It was not until the early 20th century that niobium was first used commercially. Brazil is the leading producer of niobium and ferroniobium, an alloy of niobium and iron. Niobium is used mostly in alloys, the largest part in special steel such as that used in gas pipelines. Although alloys contain only a maximum of 0.1%, that small percentage of niobium improves the strength of the steel. The temperature stability of niobium-containing superalloys is important for its use in jet and rocket engines. Niobium is used in various superconducting materials. These superconducting alloys, also containing titanium and tin, are widely used in the superconducting magnets of MRI scanners. Other applications of niobium include its use in welding, nuclear industries, electronics, optics, numismatics and jewelry. In the last two applications, niobium's low toxicity and ability to be colored by anodization are particular advantages.
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Side Effects of Iron Sucrose

Iron Sucrose
Iron sucrose is an intravenous drug approved for treatment of iron deficiency anemia in adult patients suffering from kidney disease and being treated with hemodialysis or peritoneal dialysis and/or the hormone erythropietin. Dialysis is a procedure that takes over for the kidneys, filtering blood and removing waste. Erythropietin helps stimulate the production of red blood cells.

Iron sucrose is an injectible medication that is designed to increase iron levels in the blood of those who have certain forms of anemia or kidney disease. These shots are typically administered at a doctor's office and are not approved for self-injection by the patient. Possible side effects of iron sucrose include pain or swelling at the injection site, dizziness, or headaches. Digestive problems such as nausea, diarrhea, or vomiting may also occur after receiving an injection containing this medication. A doctor should be consulted with any questions or concerns about the use of iron sucrose in an individual situation.

Side effects of iron sucrose treatment include low blood pressure, cramps, headaches, nausea, vomiting and diarrhea. Severe---sometimes fatal---immune system responses called hypersensitivity reactions have been reported in some patients treated with similar drugs. Although no fatal incidents were reported in clinical trials of iron sucrose, physicians should closely monitor patients receiving intravenous iron.

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Basic Knowledge of v-Akt phospho-Tyr326 AKT1 Polyclonal Antibody A

Akt, also known as Protein Kinase B (PKB), is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration.

 v-Akt phospho-Tyr326 AKT1 Polyclonal Antibody A Akt1 is involved in cellular survival pathways, by inhibiting apoptotic processes. Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that lead to skeletal muscle hypertrophy, and general tissue growth. Since it can block apoptosis, and thereby promote cell survival, Akt1 has been implicated as a major factor in many types of cancer. Akt (now also called Akt1) was originally identified as the oncogene in the transforming retrovirus, AKT8.

Item name: v-Akt phospho-Tyr326 AKT1 Polyclonal Antibody A
Specification: 100 µg
Applications: ELISA, WB-Ti
Immunogne: Rabbit polyclonal antibody raised against synthetic phosphopeptides of AKT1.


Polyclonal antibodies (or antisera) are antibodies that are obtained from different B cell resources. They are a combination of immunoglobulin molecules secreted against a specific antigen, each identifying a different epitope.

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Details of Lithium Sulfate Monohydrate

 Lithium sulfate monohydrate

Lithium sulfate, also known as glutamic acid lithium. Colorless monoclinic crystal or white crystalline powder, soluble in water, insoluble in acetone and ethanol. 25 degrees, the water solubility of 25.7%. Α, β, γ - three kinds of polymorphs. α-white monoclinic crystal, β-, six-party crystallization of γ-type cubic crystal. Hygroscopicity. Monohydrate lithium sulfate crystallization from concentrated aqueous solution is very stable. The role of the treatment of manic-depressive psychosis.

Item Name: Lithium sulfate monohydrate
Formula : Li2SO4 . H2O
Molecular weight : 127.94
Details of Lithium Sulfate Monohydrate:
Appearance : Hygroscopic white crystal
Density : 2.06g/cm3 @20 °C
Melting points : Dehydrates between 72°C and 160°C
Water solubility : 29.9wt%@ 25 °C
Application : Mainly used as piezoelectric material
Packing : In plastic bag lined with PE bag, or according to customer's request.

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Simple Information of aFGF

 aFGF

Item name:aFGF
Purity: >97(%)
Activity: With the test
Toxicity: With the test
Specifications of aFGF:
Stock solution: 50 ml/100mL/500mL/1000mL (per bottle)
Powder: 0.1g/0.2g/0.5g/1g(per bottle)
Solvent agent: 10mL/50mL/100mL/500mL (per bottle)

Fibroblast growth factors, or FGFs, are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. The FGFs are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs are key players in the processes of proliferation and differentiation of wide variety of cells and tissues. In humans, 22 members of the FGF family have been identified, all of which are structurally related signaling molecules.

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Description of CRF (human, rat) Acetate

 CRF (human, rat) Acetate
Item Name: CRF (human, rat) Acetate
Molecular Formula: C208H344N60O63S2
CAS No.: 86784-80-7
Sequence: Ser-Glu-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-al-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn- Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2
Item Categories: Peptide;CRF receptor and related
Description of CRF (human, rat) Acetate:
Purity (HPLC)                                 98%min.
Appearance                              White powder
Single Impurity (HPLC)              1.0%max
Amino Acid Composition       ±10% of theoretical
Peptide Content (N%)                 ≥80.0%
Water Content (Karl Fische        ≤6.0%
Acetate Content (HPIC)               ≤15.0%
MS (ESI)                                     Consistent
Mass Balance                             95.0~105.0%

A case report form (or CRF) is a paper or electronic questionnaire specifically used in clinical trial research. The Case Report Form is the tool used by the sponsor of the clinical trial to collect data from each participating site. All data on each patient participating in a clinical trial are held and/or documented in the CRF, including adverse events.

The sponsor of the clinical trial develops the CRF to collect the specific data they need in order to test their hypotheses or answer their research questions. The size of a CRF can range from a handwritten one-time 'snapshot' of a patient's physical condition to hundreds of pages of electronically captured data obtained over a period of weeks or months. (It can also include required check-up visits months after the patient's treatment has stopped.)
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Introduction of Ytterbium Fluoride

 Ytterbium fluoride

Ytterbium(III) fluoride (YbF3) is an inorganic chemical compound. Ytterbium fluoride, produces low-index film layers with extremely durable mechanical properties that exhibit good transparency in the UV through infrared (14 µm ) regions. The films are insoluble and show low stress, making compounds of Ytterbium Fluoride suitable for AR coatings in the 8 to 14 µm region, including high power CO2 laser coatings.

YbF3 and BaSO4 nanoparticles were incorporated into the powder component of Riva SC (SDI Ltd., Bayswater, Australia) at 1, 2, 5, 10, 15, and 25% by weight. Capsules were assembled at a powder:liquid ratio of 2.9:1, activated and mixed, and the resultant pastes evaluated for working time, initial setting time, 24-h surface hardness and 24-h compressive strength.
Ytterbium is a chemical element with the symbol Yb and atomic number 70. It is the fourteenth and penultimate element in the lanthanide series, or last element in the f-block, which is the basis of the relative stability of the +2 oxidation state. However, like the other lanthanides, the most common oxidation state is +3, seen in its oxide, halides and other compounds. In an aqueous solution, like compounds of other late lanthanides, soluble lutetium compounds form a complex with nine water molecules.

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Tuesday, June 5, 2012

Some Knowledge of 2-Cyclohexen-1-One

 2-cyclohexen-1-one
Item name: 2-cyclohexen-1-one
CAS No.: 930-68-7
Molecular formula: C6H8O
Molecular weight: 96.13
Purity(HPLC): 97%min (GC)
Appearance: Colorless liquid

Cyclohexen (1,2,3,4-Tetrahydrobenzol) ist eine farblose Flüssigkeit mit der Summenformel C6H10. Sie gehört zu den Cycloalkenen (cyclische Kohlenwasserstoffe mit mindestens einer Doppelbindung).

Glutathione is able to protect membrane proteins from oxidative stress. In ischemia/reperfusion injury, free radicals cause synaptosomal membrane protein and lipid oxidation that is prevented by the free radical scavenger N-tert-butyl-alpha-phenylnitrone (Hall N. C. et al. (1995) Neuroscience 64, 81-89; 69, 591-600). We wondered if diminution of glutathione would lead to further membrane alterations. Accordingly, the effects of glutathione depletion, by intraperitoneal administration of 2-cyclohexene-1-one, on the physical state of cortical synaptosomal membrane proteins and lipids, with and without global ischemia/reperfusion, were studied in vivo and in vitro in adult and aged gerbils utilizing electron paramagnetic resonance spectrometry. 2-Cyclohexene-1-one (100 mg/kg, i.p.) was administered 30 min prior to 10-min ischemia followed by 1 or 14 h reperfusion.
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Clinical Efficacy of Nevirapine


Nevirapine, also marketed under the trade name Viramune (Boehringer Ingelheim), is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used to treat HIV-1 infection and AIDS. As with other antiretroviral drugs, HIV rapidly develops resistance if nevirapine is used alone, so recommended therapy consists of combinations of three or more antiretrovirals.

Nevirapine in triple combination therapy has been shown to suppress viral load effectively when used as initial antiretroviral therapy (i.e., in antiretroviral-naive patients). Some clinical trials have demonstrated comparable HIV suppression with nevirapine-based regimens to that achieved with protease inhibitors (PIs) or efavirenz. Although concerns have been raised about nevirapine-based regimens in those starting therapy with high viral load or low CD4 count, some analyses suggest that nevirapine may be effective in these patients.

Nevirapine may also form a useful component of salvage regimens after virological failure, usually in combination with one or more PIs as well as nRTIs, especially in those who have not previously taken an NNRTI.

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What Is Vinyl Fluoride?

Vinyl fluoride is an organic halide with the chemical formula C2H3F. It is a colorless gas with a faint etherlike odor. It is used as the monomeric precursor to the fluoropolymer polyvinylfluoride.

Vinyl fluoride (VF) is reasonably anticipated to be a human carcinogen based on evidence of tumor induction at multiple organ sites in rats and mice. Inhalation exposure of rats to vinyl fluoride resulted in increased incidences of hepatic hemangiosarcomas, hepatocellular adenomas or carcinomas, and Zymbal gland carcinomas; inhalation exposure of mice to VF resulted in increased incidences of hepatic hemangiosarcomas, bronchiolar-alveolar adenomas or adenocarcinomas, hepatocellular adenomas, mammary gland adenocarcinomas, and Harderian gland adenomas (Bogdanffy et al. 1995; IARC 1995). The tumor response to VF in laboratory animals is similar to the responses to vinyl chloride, a known human carcinogen (NTP 1998; IARC 1987), and to vinyl bromide, a probable human carcinogen (IARC 1986). A unique feature of vinyl chloride carcinogenicity is the induction of rare hepatic hemangiosarcomas in rats and mice and the causal association in epidemiological studies between vinyl chloride exposure and excess risk of hemangiosarcoma of the liver (NTP 1998). The fact that VF, vinyl chloride, and vinyl bromide induce rare hemangiosarcomas of the liver in experimental animals and induce the formation of similar DNA adducts suggests a possible common mechanism of carcinogenicity for these vinyl halides.
Vinyl fluoride is a member of the vinyl halide class. VF and the other vinyl halides are used ubiquitously in industry, especially in manufacture of plastics. They are easily polymerized and copolymerized with various materials, such as acrylonitrile, vinyl acetate, and styrene, to form pliable lightweight plastics or thermoplastic resins (HSDB 1995). VF (C2H3F, mol wt 46.044, CASRN 75-02-5) also is known as fluoroethene. It is
a colorless gas at ambient temperature and pressure and is highly flammable. VF is used in the production of polyvinyl fluoride and other fluoropolymers and as an intermediate in organic synthesis.
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Features of 1,1-Difluoroethylene


Item Name: 1,1-Difluoroethylene
Molecular Formula: C2H2F2
CAS No.: 75-38-7
Features of 1,1-Difluoroethylene:
mw   64.03
mp  −144 °C(lit.)
bp  −83 °C(lit.)
density  0,617 g/cm3
vapor density  2.2 (vs air)
vapor pressure  518 psi ( 21 °C)
Fp  <-60°C

1,1-Difluoroethylene is a hydrofluoroolefin. Global production in 1999 was approximately 33,000 metric tons. It is primarily used in the production of fluoropolymers such as polyvinylidene fluoride. Laser Stark spectra are given for 1,1difluoroethylene (H2CCF2) using laser λ = 337 μm. Three families of resonances are analyzed, two of them being the related transitions J(Ka, Kc) = 47(40, 8) ← 46(40, 7) and 47(40, 7) ← 46(40, 6). Relationships between the two transitions permit the calculation of both the zero-field transition frequencies and the effective dipole moment. A third family is assigned as 38(32, 7) ← 37(30, 8). The Stark shift is quasi-linear with E field, dominated by near-degenerate doublet interactions. Extended measurements and a reanalysis of the microwave spectrum are reported, in connection with the analysis of the far infrared spectrum.

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Wikipedia's Definition of Stanozolol


Stanozolol, commonly sold under the name Winstrol (oral), Tenabol and Winstrol Depot (intramuscular), is a synthetic anabolic steroid derived from dihydrotestosterone. It was developed by Winthrop Laboratories (Sterling Drug) in 1962, and has been approved by the FDA for human use.
 Stanozolol
Unlike most injectable anabolic steroids, stanozolol is not esterified and is sold as an aqueous suspension, or in oral tablet form. The drug has a high oral bioavailability, due to a C17 α-alkylation which allows the hormone to survive first-pass liver metabolism when ingested. It is because of this that stanozolol is also sold in tablet form.

Stanozolol is usually considered a safer choice for female bodybuilders in that its anabolic effects predominate over its androgenic effects, although virilization and masculinization are still very common even at low doses.

Stanozolol has been used in both animal and human patients for a number of conditions. In humans, it has been demonstrated to be successful in treating anaemia and hereditary angioedema. Veterinarians may prescribe the drug to improve muscle growth, red blood cell production, increase bone density and stimulate the appetite of debilitated or weakened animals.

Stanozolol is one of the anabolic steroids commonly used as a performance enhancing drug and is banned from use in sports competition under the auspices of the International Association of Athletics Federations (IAAF) and many other sporting bodies. Additionally, stanozolol has been used in US horse racing.

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General Introduction of Testosterone Enanthate


Testosterone enanthate is an ester of the naturally-occurring steroid hormone testosterone. In the body, it is directly involved in the production of semen. As an androgen, it also stimulates muscle growth and increases bone density. It is used for a number of medical purposes, including hormone replacement therapy. Users must inject it directly into the muscle tissue. Typical dosages vary, and individuals must take care to avoid a number of injection site complications.

For males, testosterone entanthate is prescribed for conditions such as primary hypogonadism, hypogonadotropic hypogonadism, and delayed puberty. Doctors may prescribe it for females with metastatic mammary cancer.
 Testosterone Enanthate Testosterone is a steroid hormone from the androgen group and is found in mammals, reptiles, birds, and other vertebrates. In mammals, testosterone is primarily secreted in the testicles of males and the ovaries of females, although small amounts are also secreted by the adrenal glands. It is the principal male sex hormone and an anabolic steroid.

In men, testosterone plays a key role in the development of male reproductive tissues such as the testis and prostate as well as promoting secondary sexual characteristics such as increased muscle, bone mass, and the growth of body hair. In addition, testosterone is essential for health and well-being as well as the prevention of osteoporosis.

On average, an adult human male body produces about 7-8 times more testosterone than an adult human female body, but females are more sensitive to the hormone. Testosterone is observed in most vertebrates. Fish make a slightly different form called 11-ketotestosterone. Its counterpart in insects is ecdysone. These ubiquitous steroids suggest that sex hormones have an ancient evolutionary history.

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Some Information of Anti-GABA-ARα1 γ1

 Anti-GABA-ARα1 γ1

Specification: 100ul/200ul/1ml
The GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB.

GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known as metabotropic receptors).

It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. Members of this superfamily, which includes nicotinic acetylcholine receptors, GABAA receptors, glycine and 5-HT3 receptors, possess a characteristic loop formed by a disulfide bond between two cysteine residues.

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Knowledge of Vital Wheat Gluten


Wheat gluten, also called wheat meat, mock duck, gluten meat, or simply gluten, is a food made from gluten, the main protein of wheat. It is made by washing wheat flour dough with water until all the starch dissolves, leaving insoluble gluten as an elastic mass which is then cooked before being eaten.

Wheat gluten is an alternative to soybean-based meat substitutes such as tofu. Some types of wheat gluten have a chewy or stringy texture that resembles meat more than other substitutes. Wheat gluten is often used instead of meat in Asian, vegetarian, Buddhist, and macrobiotic cuisines. Simulated duck is a common use for wheat gluten.

Bread bakers often add vital wheat gluten to bread dough to enhance the dough and improve the baked results of bread. Vital wheat gluten is especially beneficial when you add it to breads that contain whole wheat and rye grains because it produces higher and lighter loaves of bread. Because vital wheat gluten is pure protein derived from the wheat kernel, storing this grain is similar to storing any flour product.

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Uses of Raw Material Supply Short Lactobacillus Colon


Raw material supply short lactobacillus colon is a common kind of lactobacillus. It is mainly used:
  • for short cl.perfringen lactobacillus gram-positive bacterium, the optimum growth temperature is 37 degrees Celsius, absolute anaerobic, do not have high mobility, is the largest newborn intestinal flora.
  • as antibiotic resistant to acid, sensitive, mostly distributed in the colon. Raw material supply short lactobacillus colon can inhibit the growth of harmful bacteria and the intestine to help digestion, decomposition of carbohydrates as many as 20 and natural antibiotic and lactic acid, larger pieces of food get broken down into smaller pieces while being prepared for chemical digestion. Mechanical digestion starts in the mouth and continues into the stomach.
The colon is the last part of the digestive system in most vertebrates; it extracts water and salt from solid wastes before they are eliminated from the body, and is the site in which flora-aided (largely bacterial) fermentation of unabsorbed material occurs. Unlike the small intestine, the colon does not play a major role in absorption of foods and nutrients. However, the colon does absorb water, sodium and some fat soluble vitamins.

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Description of PPAHV

 PPAHV

Item name: PPAHV
CAS NO: 175796-50-6
Molecular formula: C39H44O11
Molecular weight: 688.77
Product description: PPAHV is soluble in DMSO and in ethanol and Non-pungent resiniferatoxin-type phorboid vanilloid. Agonist at rat TRPV1 (EC50 between 3 and 10?M) but virtually inactive at human TRPV1 (EC50>10?M). Induces apoptosis through a TRPV-independent mechanism. Tumor promotor.
Mutation of methionine  547 in S4 of rat TRPV1 to leucine, found in human TRPV1 (M547L), reduced the ability of PPAHV to activate TRPV1 by approximately 20 fold. The reciprocal mutation of human TRPV1 (L547M) enabled the human receptor to respond to PPAHV. These mutations did not significantly affect the agonist activity of capsaicin, resiniferatoxin (RTX) or olvanil in [Ca2+]i assays. Introducing the equivalent mutation into guinea pig TRPV1 (L549M) increased the agonist potency of PPAHV by > 10 fold in the [Ca2+]i assay and increased the amplitude of the evoked current.  The rat M547L mutation reduced the affinity of RTX binding. Determinants of capsazepine  and PPAHV function in TRPV1.
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Properties of Isonipectoamide


 Isonipectoamide Item name: Isonipectoamide
CAS: 39546-32-2
Molecular Formula: C6H12N2O
Formula Weight: 128.17
Properties of Isonipectoamide:
Density: 1.06 g/cm3
Melting Point: 145-148 °C
Boiling Point: 311.7 ºC at 760 mmHg
Flash Point: 142.3 ºC
Appearance: White to light yellow crystalline powder.
Use: Used as medicine intermediate.
In (IV), head-to-tail primary cation-anion associations are extended longitudinally into chains through the water-bridged cation associations, and laterally by piperidinium-carboxylate N-H···O and water-carboxylate O-H···O hydrogen bonds. The structures reported here further demonstrate the utility of the isonipecotamide cation as a synthon for the generation of stable hydrogen-bonded structures. An additional example of cation-anion association with this cation is also shown in the asymmetric three-centre piperidinium-carboxylate N-H···O,O' interaction in the first-reported structure of a 2:1 isonipecotamide-carboxylate salt.
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An Introduction of Phenylacetone

 Phenylacetone

Item name: Phenylacetone
CAS:1 03-79-7
Molecular Weight: 134.18g/mol
Molecular Formula: C9H10O

Phenylacetone (known also as phenyl-2-propanone, benzyl methyl ketone, or methyl benzyl ketone), is an organic compound. It is a clear oil with a refractive index of 1.5168. This substance is used in the manufacture of methamphetamine and amphetamine as a starting material or intermediate, where it is commonly known as P2P. Due to the illicit uses in clandestine chemistry, it was declared a schedule II controlled substance in the United States 11 February 1980.

Phenylacetone can also be produced from many other compounds. For example:
•phenylacetic acid is distilled with lead acetate or calcium acetate to yield phenylacetone.
•benzaldehyde is reacted with nitroethane yielding phenyl-2-nitropropene, which is reduced, usually in the presence of acid, to phenylacetone.
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Some Knowledge of Zirconium Carbide Nanopowder

Zirconium Carbide Nanopowder
97-99% , 30-60nm
Chemical formula: ZrC
Purity: 97-99%
[O]< 0.6-1%
APS: 40-60nm
SSA: 70 m2/g
Crystal cell: Cubic
True density: 2.7 g/cm3
Bulk Density: 0.08 g/cm3
Color:  Black

Zirconium Ccarbide nanopowder is an important refractory material with hardness over SiC, higher strength and ductile, good thermal conductivity. The nanopowder increases activity, strength, ductile, absorption of microwave and light (of wavelength <2um most) or reflection back the IR from human body for heat storage, and lower sintering temperature.

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Chemistry of Cupric Oxide

Copper(II) oxide or cupric oxide (CuO) is the higher oxide of copper. As a mineral, it is known as tenorite.
It is a black solid with an ionic structure which melts above 1200 °C with some loss of oxygen. It can be formed by heating copper in air:
2 Cu + O2 → 2 CuO

Here, it is formed along with copper(I) oxide as a side product; thus, it is better prepared by heating copper(II) nitrate, copper(II) hydroxide or copper(II) carbonate:
2 Cu(NO3)2 → 2 CuO + 4 NO2 + O2
Cu(OH)2 (s) → CuO (s) + H2O (l)
CuCO3 → CuO + CO2
Cupric Oxide
Copper(II) oxide is a basic oxide, so it dissolves in mineral acids such as hydrochloric acid, sulfuric acid or nitric acid to give the corresponding copper(II) salts:
CuO + 2 HNO3 → Cu(NO3)2 + H2O
CuO + 2 HCl → CuCl2 + H2O
CuO + H2SO4 → CuSO4 + H2O

It reacts with concentrated alkali to form the corresponding cuprate salts:
2 XOH + CuO + H2O → X2[Cu(OH)4]

It can also be reduced to copper metal using hydrogen or carbon monoxide:
CuO + H2 → Cu + H2O
CuO + CO → Cu + CO2

A laboratory method for preparing copper(II) oxide is to electrolyze water containing sodium bicarbonate at a moderate voltage with a copper anode, collect the mixture of copper hydroxide, basic copper carbonate, and copper carbonate produced, and heat it.

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An Introduction of Organic Waste Gas Purification Catalyst

 Organic waste gas purification catalyst

Appearance: Black grey
Grain size: Φ3-5mm
The compressive strength: ≥60N/grain
Bulk density: ~0.76 g/ml
The Surface area: ~120 m2/g
Gas airspeed: 5000~10000h-1

Organic waste gas purification catalyst is the use of high-temperature catalyst materials with high specific surface and high performance rare earth oxygen storage material as the carrier, nano-perovskite-type oxide as the main active ingredients, with a high dispersion rate uniformly distributed prepared from monolithic catalyst, is a new and efficient catalyst for various types of industrial waste gas purification. Rare-earth perovskite-type oxides are effective catalysts of carbon monoxide, and life is better than its initial activity precious metal catalysts, catalytic combustion and NOX reduction with the dual role. Perovskite-type rare-earth and because the combustion catalyst has good thermal stability of hydrocarbons in a wide temperature range of combustion into CO2 and H2O have a good catalytic activity. The catalyst for the Treatment of carbon monoxide, hydrocarbons and their oxygenated derivatives of industrial emissions.

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Knowledge of BAR ELISA Kit

 BAR ELISA Kit


Bifunctional apoptosis regulator (BAR) is an endoplasmic reticulum protein that interacts with both the extrinsic and intrinsic apoptosis pathways. We hypothesize that over-expression of BAR Delta RING prevents apoptosis and injury following ischaemia/reperfusion (I/R) and attenuates doxorubicin (DOX)-induced cardiotoxicity.

Item name: BAR ELISA Kit
Specification: 96Test

ELISA can perform other forms of ligand binding assays instead of strictly "immuno" assays, though the name carried the original "immuno" because of the common use and history of development of this method. The technique essentially requires any ligating reagent that can be immobilized on the solid phase along with a detection reagent that will bind specifically and use an enzyme to generate a signal that can be properly quantified. In between the washes only the ligand and its specific binding counterparts remain specifically bound or "immunosorbed" by antigen-antibody interactions to the solid phase, while the nonspecific or unbound components are washed away. Unlike other spectrophotometric wet lab assay formats where the same reaction well (e.g. a cuvette) can be reused after washing, the ELISA plates have the reaction products immunosorbed on the solid phase which is part of the plate and thus are not easily reusable

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The Explanation of Oxymetholone


 Oxymetholone

Oxymetholone, marketed as Anadrol, is a synthetic anabolic steroid developed in 1960 by Zoltan 'Anadrol Z' F. Its primary clinical applications include treatment of osteoporosis and anaemia, as well as stimulating muscle growth in malnourished or underdeveloped patients. The drug was approved for human use by the FDA. Later, non-steroidal drugs such as epoetin alfa were developed and proven to be more effective as a treatment for anaemia and osteoporosis without the side effects of oxymetholone. The drug remained available despite this and eventually found a new use in treating HIV wasting syndrome. Presented most commonly as a 50 mg tablet, oxymetholone is one of the strongest androgenic steroids available. Similarly, it also poses the greatest risk of side effects of any steroid. Despite very low binding affinity with the androgen receptor, oxymetholone is highly effective in promoting extensive gains in body mass, mostly by greatly improving protein synthesis. For this reason, it is often used by bodybuilders and athletes. Many athletes also use oxymetholone as a method of protection for the joints under heavy loads. Due to the high water retention users experience from this drug, it similarly lubricates the joints and helps protect from injury. Oxymetholone is widely considered by bodybuilders to have the strongest anabolic effect out of all oral steroids available.

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The Synthesis of Fluoxymesterone


 Fluoxymesterone
Item Name: Fluoxymesterone
Chemical Name: (11beta,17beta)-9-Fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one
Molecular Formula: C20H29FO3
CAS No.: 76-43-7
Description:  white crystalline powder.
Specification: Enterprise Standard

Fluoxymesterone (trade name Halotestin) is an anabolic steroid with strong androgenic properties that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. It is approximately 5 times as potent as methyltestosterone. The antitumor activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.

Fluoxymesterone can be prepared from 11α-hydroxy-17-methyltestosterone.

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What Is 4-hydroxytestosterone?


 4-hydroxy testosterone

Item Name: 4-hydroxy testosterone
Chemical Name: 4-Androsten-4,17β-ol-3-one
Molecular Formula: C19H28O3
Description: white crystalline powder.
Specification: Enterprise Standard

4-Hydroxytestosterone (4-OHT or 4,17beta-dihydroxy-4-androstene-3-one) is an anabolic steroid. It was first patented by G.D. Searle & Company in 1955 and is testosterone with a hydroxy group at the four position. 4-OHT has moderate anabolic, mild androgenic, and anti-aromatic properties and is similar to the steroid clostebol.

4-Hydroxytestosterone  is a legal steroidal compound that is relatively new to the market. Unlike prohormones, 4-OHT does not require enzymatic conversion to have an anabolic effect. It was first patented by G.D. Searle & Co. in 1955, but it did not reach the commercial market, and has recently become available as a dietary supplement. Chemically, 4-OHT is testosterone with a hydroxy group at the four position, making it most similar to the steroid clostebol, which has a chloro group at the four position. These two compounds are also very similar in effect.

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Basic Description of N-[2-(5-Hydroxy-1H-indol-3-yl)Ethyl]-5,8,11,14-Eicosatetraenamide

 N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide

Item name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
CAS NO,: 187947-37-1
Molecular Formula: C30H42N2O2
Molecular Weight: 462.32
Description of N-[2-(5-Hydroxy-1H-indol-3-yl)Ethyl]-5,8,11,14-Eicosatetraenamide: Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC 50 values are 5.6 μ M and 37-40 nM for FAAH and TRPV1 respectively). Inactive at cPLA 2 , CB 1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

N-Ethyl-3-piperidyl benzilate is less potent and shorter acting than 3-quinuclidyl benzilate, but like 3-QNB its effects on the central nervous system predominate over peripheral effects. It produces deliriant and hallucinogenic effects similar to those of plants such as datura and may be used recreationally at low doses, however unpleasant side effects such as dysphoria, nausea and vomiting, dizziness and extreme dry mouth tend to make abuse of these kind of drugs uncommon. Both the N-methyl and N-ethyl analogues of 3-piperidyl benzilate are however Schedule I controlled drugs.


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Benefits of Whey Powder



Whey powder is a manufactured nutritional supplement and food additive that comes from milk and is used for human and animal consumption. It is a by-product of the manufacture of cheese or casein. Whey powder is high in protein and lactose. Its appearance is creamy white and it has a bland flavor.

Whey powder is made from drying Whey or liquid plasma. This is the liquid that remains behind in the cheese making process after milk has been curdled by the addition of Rennet and strained. Therefore,
whey is a by-product in the manufacture of cheese.

Protein is a necessary component of a healthy diet. Vegetarians often are looking for ways to add protein to their diets, and whey protein is a good choice for those who eat milk products. Dietitians recommend that people with diabetes have protein in each meal, and this is a way to add it to foods. Athletes also look for protein to help build body muscle.

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Yttrium Oxide's Uses in Materials Science

 Yttrium oxide

Yttrium oxide, also known as yttria, is Y2O3. It is an air-stable, white solid substance. Yttrium oxide is used as a common starting material for both materials science as well as inorganic compounds.

It is the most important yttrium compound and is widely used to make Eu:YVO4 and Eu:Y2O3 phosphors that give the red color in color TV picture tubes. Yttrium oxide is also used to make yttrium iron garnets, which are very effective microwave filters.

Y2O3 is used to make the high temperature superconductor YBa2Cu3O7, known as "1-2-3" to indicate the ratio of the metal constituents:
2 Y2O3 + 8 BaO + 12 CuO + O2 → 4 YBa2Cu3O7
This synthesis is typically conducted at 800 °C.

The thermal conductivity of yttrium oxide is 27 W/(m·K).[2
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Description of Chromium Citrate

 Chromium Citrate


Item name: Chromium Citrate
Molecular Formula: C6H5CrO7
Formula Weight: 241.1g/mol
Description: Chromium citrate is produced by the reaction of citric acid with a chromium salt. It is a highly specialised product finding used in the leather and textile industries, metal treatment and pharmaceutical manufacturing.

The chromium citrate complex [CrCIT] was synthesized and its structure was determined by infrared, UV-visible and atomic absorption spectroscopy, elemental and thermodynamic analysis. Anti-diabetic activity, oxidative DNA damage capacity and acute oral toxicity of [CrCIT] were investigated and compared with that of chromium trichloride hexahydrate. [CrCIT] was synthesized in a single step reaction by chelating chromium(III) with citric acid in aqueous solution. The molecular formula of [CrCIT] was inferred as CrC(6)H(5)O(7)·4H(2)O. The anti-diabetic activity of the complex [CrCIT] was assessed in alloxan-diabetic rats by daily oral gavage for 3 weeks. The biological activity results showed that the complex at the dose of 0.25-0.75 mg Cr/kg body weight could decrease the blood glucose level and increase liver glycogen level in alloxan-diabetic rats.

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Ritonavir's Method of Action

Ritonavir, with trade name Norvir (Abbott Laboratories), is an antiretroviral drug from the protease inhibitor class used to treat HIV infection and AIDS.

Ritonavir is frequently prescribed with HAART, not for its antiviral action, but as it inhibits the same host enzyme that metabolizes other protease inhibitors. This inhibition leads to higher plasma concentrations of these latter drugs, allowing the clinician to lower their dose and frequency and improving their clinical efficacy.

Ritonavir was originally developed as an inhibitor of HIV protease. It is one of the most complex inhibitors. It is now rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). The drug's molecular structure inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors. This discovery, which has drastically reduced the adverse effects and improved the efficacy of PI's and HAART, was first communicated in an article published in the AIDS Journal in 1997 by the University of Liverpool. This effect does come with a price: it also affects the efficacy of numerous other medications, making it difficult to know how to administer them concurrently. In addition it can cause a large number of side-effects on its own.

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Characteristics of Lactobacillus Fermentum


Lactobacillus fermentum is a Gram-positive species of bacterium in the genus Lactobacillus. It is associated with active dental caries lesions. It is also commonly found in fermenting animal and plant material. It has been found in sourdough. A few strains are considered probiotic or "friendly" bacteria in animals  and at least one strain has been applied to treat urogenital infections in women. Some strains of lactobacilli formerly classified as Lactobacillus fermentum (such as RC-14) have since been reclassified as Lactobacillus reuteri. Commercialized strains of L. fermentum used as probiotics include PCC and ME-3.

Lactobacillus fermentum belongs to the genus Lactobacillus. Species in this genus are used for a wide variety of applications. These applications include food and feed fermentation. It has been found that some strains for Lactobacillus fermentum have natural resistances to certain antibiotics and chemotherapeutics. They are considered potential vectors of antibiotic resistance genes from the environment to humans or animals to humans.

Lactobacillus fermentum can also be a normal inhabitant of the human intestinal tract and some strains have been associated with cholesterol metabolism.
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Monday, June 4, 2012

Specifications of Tetrahydrothiopyran-4-One

 Tetrahydrothiopyran-4-one
CAS: 1072-72-6
Molecular Formula: C5H8OS
Formula Weight: 116.18
Specifications of Tetrahydrothiopyran-4-One:
Density: 1.134 g/cm3
Melting Point :60-64 °C(lit.)
Boiling Point: 218.7 °C at 760 mmHg
Flash Point: 105.5 °C
Appearance: White to pale yellow crystalline solid
Use: Used as medicine intermediate
As shown, with 5 mol% of 1,1-dioxotetrahydrothiopyran-4-one as catalyst,10 epoxidation of various olefins (2-mmol scale) in a homogeneous acetonitrile-water solvent system with 1.5 equiv of Oxone ® at room temperature can be achieved in a short period of time with excellent yields of epoxides (80-97%) isolated by flash column chromatography.2 As the pH of the reaction is maintained at 7-7.5 by sodium bicarbonate , acid- or base-labile epoxides (entries 12-14) can be easily isolated without decomposition. More importantly, the in situ epoxidation of olefins can be performed on a large scale directly with 5 mol% of tetrahydrothiopyran-4-one , which is oxidized immediately by Oxone ® to 1,1-dioxotetrahydrothiopyran-4-one during the epoxidation reactions. For example, with 5 mol% of tetrahydrothiopyran-4-one , substrates 3, 5 (20 mmol each) and 11 (100 mmol) were epoxidized with excellent isolated yields of epoxides (91-96%).
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