Rapamycin Complex 1 (Rapamycin1) is composed of Rapamycin , regulatory-associated protein of Rapamycin (Raptor), mammalian LST8/G-protein β-subunit like protein (mLST8/GβL) and the recently identified partners PRAS40 and DEPTOR. This complex is characterized by the classic features of Rapamycin by functioning as a nutrient/energy/redox sensor and controlling protein synthesis.The activity of this complex is stimulated by insulin, growth factors, serum, phosphatidic acid, amino acids (particularly leucine), and oxidative stress.
Rapamycin1 is inhibited by low nutrient levels, growth factor deprivation, reductive stress, rapamycin, and farnesylthiosalicylic acid (FTS).The two best characterized targets of mTORC1 are p70-S6 Kinase 1 (S6K1) and 4E-BP1, the eukaryotic initiation factor 4E (eIF4E) binding protein 1.
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