Rapamycin usage and dosage

Rapamycin treatment options varied, and the separate and joint administration of the dose CsA or FK506 dose of such drug use vary widely. Also have to maintain plasma concentration differences. Groth, etc. in the rapamycin-based immunosuppressive therapy with CsA-based immunosuppressive therapy in the control study, the initial dose of oral rapamycin to 16-24mg/m2/day, followed by 7-10 days amount of 8-12mg/m2/day, plasma concentrations in the 30ng/ml, 2 months after rapamycin dosage adjustment until plasma concentrations in the 15ng/ml, both with water or orange juice in the morning one blunt, one Day one, first 12 weeks of weekly monitoring of blood concentration of 1, followed by monthly monitoring 1. Observed plasma concentration and is proportional to drug toxicity, but its side effects are reversible. When the plasma concentration is reduced, the side effects are better. So that the plasma concentration Groth to keep in 10-20ng/ml as well. Kahan that the plasma concentration greater than 15ng/ml, that with the increase of triglycerides and hemoglobin, white blood cells or platelets to reduce the. When RAPA and FK506, when combined, the plasma concentration that is maintained at 6-12ng/ml reduce the role of acute rejection rate, and toxicity.Read more：http://www.acid-lactic-bacteria.com/bulk-drug/Rapamycin/