Bullingham so that, regardless of oral or intravenous administration, MMF can be rapidly and extensively absorbed by the body, and its active metabolites before the loop entirely the product of mycophenolic acid. Two routes of MPA concentration-time curves are similar. The average time to peak of mycophenolic acid (tmax) approximately 1h. The average half-life of mycophenolic acid (t1 / 2) is about 17h, prompt medication twice a day is more appropriate. Two routes of mycophenolic acid concentration - time area under the curve (AUC ∞) was no significant difference, about 105mg.h / L. Mycophenolic acid excretion into the urine by tubular secretion. MMF oral radiolabeled dose administered can be completely recovered, of which 93% appears in the urine, 6% in feces, most of the type to MPAG by the urine, traces of the type of MPA excreted by the urine . Shaw and other three factors that regulate clearance of mycophenolic acid: (1), liver, gastrointestinal tract UGT; (2) MPA-EHC; (3) of mycophenolic acid freeness. Mycophenolic acid clearance can cause major changes or related factors include: acute or chronic renal insufficiency, with immunosuppressive agents such as CsA and corticosteroids, time after transplantation (Another possible factor for the ethnic differences.
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